孕妇血清25羟维生素D与妊娠期高血压的相关性研究

Correlation between maternal serum 25-hydroxyvitamin D and hypertensive disorder complicating pregnancy

目的:研究孕妇血清25羟维生素D与妊娠期高血压之间的相关性。方法:采用酶联免疫分析法检测妊娠期高血压患者及正常孕妇在不同孕周的25羟维生素D水平,分析其与妊娠期高血压之间的相关性。结果:在妊娠16~21周和28~33周时,对照组25羟维生素D水平分别为(38.90±6.07)nmol/L和(49.00±12.92)nmol/L;A组为(37.80±6.63)nmol/L和(48.00±12.84)nmol/L;B组为(29.60±6.98)nmol/L和(34.80±7.76)nmol/L;C组为(23.90±3.89)nmol/L和(28.40±4.46)nmol/L。孕晚期的25羟维生素D水平较孕中期升高。A组、B组、C组在不同孕周的25羟维生素D水平为依次递减。B组、C组分别与对照组相比,孕妇血清25羟维生素D水平均显著降低,而A组与对照组相比,无明显差异(P>0.05)。结论:孕妇血清25羟维生素D水平与妊娠期高血压严重程度呈负相关。孕妇25羟维生素D水平的下降早于子痫前期临床症状的出现,可协助预测子痫前期的发生。

Objective：To study the correlation between maternal serum 25 hydroxyvitamin D and hypertensive disorder compli- cating pregnancy. Methods： Enzyme-linked immunosorbent assay （ELISA） was used to detect the levels of 25 hydroxyvitamin D in pregnant hypertensive patients and normal pregnant women at different gestational weeks to analyze the correlation between them and hypertensive disorders during pregnancy. Results： At 16 to 21 weeks and 28 to 33 weeks of gestation, the levels of 25 hydroxyvitamin D in the control group were （38. 9±6. 07） nmol/L and （49. 0±12. 92） nmol/L, respectively; in Group A （37.8±6. 63） nmol/L and （48. 0±12. 84） nmol/L; Group B was （29.6±6.98） nmol/L and （34. 8±7.76） nmol/L; Group C was （23.9±3. 89） nmol/L and （28. 4±4. 46） ） nmol/L. The level of 25 hydroxyvitamin D in the third trimester is higher than in the second trimester. The levels of 25 hydroxyvitamin D in group A, group B and group C decreased in different weeks. Compared with the control group, the serum levels of 25 hydroxyvitamin D in Group B and Group C were significantly lower than those in the control group, but there was no significant difference between Group A and the control group （P 〉0. 05）. Conclusion： The serum level of 25 hydroxyvitamin D in pregnant women is negatively correlated with the severity of hy- pertensive disorder in pregnancy. The decline in the level of 25 hydroxyvitamin D in pregnant women is earlier than the appear- ance of clinical symptoms in pre-eclampsia, which can help predict the occurrence of pre-eclampsia.