他汀类药物在急性冠状动脉综合征中的应用

The application of statins in the treatment of acute coronary syndrome

目的评价他汀类药物在急性冠状动脉综合征中的应用价值。方法 100例急性冠状动脉综合征患者随机分为对照组和试验组,每组50例。实施常规治疗为对照组;采用他汀类药物实施治疗为试验组。密切关注患者临床治疗情况,分析和比较2组患者血脂[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、三酰甘油(TG)、C-反应蛋白(CRP)]变化。结果试验组治疗后1、3、7 d CRP表达水平均低于对照组(P<0.05);试验组LDL-C、TC、TG水平显著下降,HDL-C显著上升,改善情况较优,且与对照组比较差异有统计学意义(P<0.05),2组心血管事件发生率比较,差异无统计学意义(P>0.05)。结论对冠心病急性冠状动脉综合征患者实施他汀类药物治疗,可对患者病情症状进行改善,调整患者血脂水平,疗效安全确切。

Objective To evaluate the application value of statins in the treatment of acute coronary syndrome.Methods One hundred patients with acute coronary syndrome admitted in our hospital from January 2014 to January 2016 were selected. Methods A total of 100 patients with acute coronary syndrome who were treated in our hospital from January 2014 to January 2016 were randomly divided into control group（n = 50） and experimental group（n = 50）. The patients in control group were treated by conventional therapy. However the patients in experimental group were treated by statins. The changes of blood lipid,including LDL-C,HDL-C,TC,TG and CRP,of the patients were observed and compared between two groups. Results The expression levels of CRP on 1 d,3 d,7 d after treatment in experimental group were significantly lower than those in control group（P〈0. 05）. The expression levels of LDL-C,TC and TG in experimental group were significantly decreased,and the levels of HDL-C were significantly increased,which indicated a better improvement,as compared with that in control group（P〈0. 05）. Moreover,there was no significant difference in incidence rate of cadiovascular events between the two groups（P〈0. 05）. Conclusion The application of statins in the treatment of acute coronary syndrome can improve the disease condition of patients,and regulate the levels of blood lipid of patients,with definite therapeutic effects and safety.