降钙素原、C反应蛋白测定在间质性肺疾病合并感染诊断中的价值

The value of procalcitonin and C-reactive protein in the diagnosis of interstitial lung disease complicated with infection

目的:探讨血清降钙素原(PCT)和C反应蛋白(CRP)在间质性肺疾病合并感染病人诊断中的价值。方法:选取98例间质性肺疾病病人,根据病人合并感染与否分组,其中54例合并感染(感染组),44例未合并感染(未感染组)。检测2组血清CRP、PCT水平及白细胞(WBC)水平、中性粒细胞百分率(N%)。结果:2组病人PCT水平和CRP水平差异均有统计学意义(P<0.01),而WBC水平和N%差异均无统计学意义(P>0.05);相关性分析表明,PCT、CRP水平与间质性肺炎病人感染发生均呈正相关关系(P<0.01和P<0.05);CRP和PCT诊断间质性肺炎合并感染病人的ROC曲线线下面积显著高于WBC和N%(P<0.01)。结论:PCT和CRP用于间质性肺疾病合并感染病人的临床诊断具有较高的应用价值,可以有效判断间质性肺疾病病人感染情况,效果显著,值得临床推广。

Objective： To investigate the value of serum procalcitonin（ PCT） and C-reactive protein（ CRP） in the diagnosis of interstitial lung disease complicated with infection. Methods： A total of 98 patients with interstitial lung disease were divided into the infection group（ 54 cases complicated with infection） and uninfection group（ 44 cases complicated without infection）. The serum levels of CRP,PCT,white blood cells（ WBC）,and neutrophil percentage（ N%） were measured in two groups. Results： The differences of the levels of serum PCT and CRP between two groups were statistically significant（ P〈0. 01）,and the differences of the level of WBC and N% between two groups were not statistically significant（ P〉0. 05）. Correlation analysis showed that the levels of PCT and CRP were positively correlated with infection in patients with interstitial pneumonia（ P〈0. 01 and P〈0. 05）. The area under the ROC curve of the CRP and PCT in diagnosing interstitial pneumonia was significantly higher that of WBC and N%（ P〈0. 01）. Conclusions： The clinical value of PCT and CRP in the diagnosis of patients with interstitial lung disease complicated with infection is high,which can effectively judge the infection situation of patients with interstitial lung disease,and is worthy of promotion.