上海青浦地区2016—2017年高龄人群血清胃蛋白酶原Ⅰ、Ⅱ的筛选试验

Screening test of serum pepsinogen Ⅰ and Ⅱ in senile patients from 2016 to 2017 in Qingpu area of Shanghai

目的探讨血清胃蛋白酶原Ⅰ(PG-Ⅰ)、Ⅱ(PG-Ⅱ)水平的一致性、可变性。方法血清PG-Ⅰ、PG-Ⅱ检测采用酶联免疫吸附法,其中PG-Ⅰ<41 ng/mL和(或)胃蛋白酶原Ⅰ/Ⅱ比值(PGR)<3.1的受试者行电子胃镜检查。结果 PG-Ⅰ<12 ng/mL的受试者中,PG-Ⅰ和PGR在2年间检测结果比较无显著差异(P>0.05);在PG-Ⅰ12~41 ng/mL的受试者中,PG-Ⅰ和PGR在2年间检测结果比较有显著差异(P<0.01)。结论 PG-Ⅰ和PGR检测结果对胃镜检查的选择具有指导意义。

Objective To explore the consistency and variability of serum pepsinogen Ⅰ（ PG-Ⅰ） and Ⅱ（ PG-Ⅱ）. Methods Serum PG-Ⅰ and PG-Ⅱ were detected by enzyme-linked immunosorbent assay（ ELISA）,and subjects with PG-Ⅰ less than 41 ng/mL or ratio of PG-Ⅰ to PG-Ⅱ（ PGR） less than 3. 1 were conducted with electronic gastroscopy. Results In the subjects with PG-Ⅰ less than 12 ng/mL,there were no significant differences in PG-Ⅰ and PGR between year 2016 and 2017（ P〉0. 05）. In the subjects with PG-Ⅰ ranged from 12 to 41 ng/mL,there were significant differences in PG-Ⅰ and PGR between year 2016 and 2017（ P〈0. 01）. Conclusion The results of PG-Ⅰ and PGR have guiding significance for the selection of gastroscopy.