中性粒细胞与恶性肿瘤关系的研究进展

Research progress in the relationship between neutrophils and malignant tumors

近年来一些研究探讨了中性粒细胞在癌症中的调控功能,并阐明了其微妙的平衡。中性粒细胞通过微环境相关的方式发挥促肿瘤或抗肿瘤的作用,其是否促进或限制肿瘤的生长、发展及转移取决于中性粒细胞表面上大量的细胞因子受体,从而对各种信号作出反应。本文对不同角色的中性粒细胞在肿瘤中发挥的不同作用做一综述,探讨治疗恶性肿瘤的中性粒细胞水平潜在的治疗靶点,加强中性粒细胞的抗肿瘤活性,同时限制其促肿瘤特性,为肿瘤临床治疗提供新的思路。

In recent years,some studies have demonstrated how neutrophil function is regulated in cancer and elucidate the delicate balance. Neutrophils express tumor-promoting or anti-tumor properties in a microenvironment related manner. Whether or not they promote or limit tumor growth,development and metastasis depends on the large number of cytokine receptors on the surface of neutrophils. It can respond to various signals. This review summarizes the different effects on different roles of neutrophils in tumors,identifying potential therapeutic targets for the treatment of neutrophils at malignant neoplasms,strengthening the anti-tumor activity of neutrophils and limiting their promotion of tumorigenesis. These characteristics provide a new idea for the clinical treatment of tumors.