上海市人群2004—2008年胆囊癌生存率分析

Gallbladder cancer survival analysis between 2004 and 2008 in Shanghai

【目的】分析上海市2004—2008年发病的胆囊癌患者的生存情况,为胆囊癌综合防治提供参考依据。【方法】对上海市肿瘤登记处2004—2008年胆囊癌患者的登记和生存随访资料,采用寿命表法和Ederer II法计算不同人口学特征和疾病诊疗特征的胆囊癌患者的观察生存率(OS)和相对生存率(RS)。【结果】2004—2008年上海市胆囊癌患者的5年OS为12.07%,RS为19.32%。不同年龄段胆囊癌患者的5年OS差异有统计学意义(P<0.01),以75岁及以上年龄段患者的5年OS最低,仅为5.98%。诊断时分期为Ⅰ期、Ⅱ期的胆囊癌患者生存率高于Ⅲ期、Ⅳ期患者。肿瘤部位位于胆囊的患者生存率高于其他部位。腺癌患者与其他病理组织学类型的胆囊癌患者生存率差异无统计学意义。不同性别及市、郊区患者的生存率差异无统计学意义。与1972—1976年相比,2004—2008年上海市男、女性胆囊癌患者的RS均有所上升。【结论】上海市胆囊癌患者的生存率逐步提高,但与其他常见恶性肿瘤相比生存率仍较低。年龄、肿瘤分期、亚部位、组织学类型对胆囊癌生存率有影响。

[Objective] To analyze survival rates of gallbladder cancer in Shanghai during 2004-2008.[Methods]Data on gallbladder cancer cases diagnosed from 2004 to 2008 was from the Shanghai Cancer Registry,and so was the follow-up information. Life Table and Ederer II were used to calculate observed survival（ OS） and relative survival（ RS） in gallbladder cancer survivors with different demographic characteristics and diagnostic status. [Results] Five-year OS and RS of gallbladder cancer in Shanghai during2004-2008 were 12. 07% and 19. 32%,respectively. Significant difference existed among different age groups in patients with 5-year OS（ P〈0. 01）. Seventy five years old and above had the lowest 5-year OS,only 5. 98%. The survival rates in stage Ⅰ and stage Ⅱ was higher than those in stage Ⅲ and stage Ⅳ.But the survival rate of cancer in gallbladder was higher than in other subsites. In addition,the survival of adenocarcinoma had no difference with other histologic types. Survival rates of gallbladder cancer did not vary by gender and residential areas. In the past 30 years,the relative survival rates in urban area of Shanghai had a certain increase both in man and women. [Conclusion] Significant differences in survival rates have been found among various age,diagnostic stages,subsites,and tumor histological types. The5-year OS and RS increase significantly in Shanghai over the past three decades,but far below the other common cancer types.