γ-氨基丁酸对LPS介导的机体炎性反应影响的研究进展

Research Progress on Effect of γ-aminobutyric Acid on LPS-mediated Inflammation to the Body

γ-氨基丁酸(γ-aminobutyric acid,GABA)是哺乳动物体内一种重要的神经性抑制递质,主要分布在中枢神经系统,具有广泛的调控功能。GABA可通过下丘脑-垂体-肾上腺皮质(HPA)轴参与机体稳态的调节,并对外界有害刺激引起的机体炎性反应具有一定的缓解作用。机体在外界应激条件刺激下会引起血液中脂多糖(LPS)含量的升高并激活Toll样受体-4(TLR4)/NF-κB信号通路,引起肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)等的表达增多,最终导致机体产生炎症反应。GABA可在机体发生炎症反应时,通过调节相应炎性因子的表达来降低炎症反应对机体造成的损伤。作者通过对GABA生理学功能与受体类别及GABA在机体发生炎性反应时的作用进行综述,对GABA在机体发生炎性反应时的影响及其与LPS引起的机体炎性反应之间的关系进行分析,为临床上采用GABA治疗机体炎性反应提供理论依据。

γ-aminobutyric acid（GABA）is an important neurotransmitter in mammals,it is mainly distributed in the central nervous system,with a wide range of regulatory functions.GABA can participate in the regulation of body homeostasis through the hypothalamic-pituitary-adrenocortical（HPA）axis,and it has a certain mitigation effect on the inflammatory response caused by harmful stimuli outside.The body will causes the increase of blood lipopolysaccharide（LPS）content under the stimulation of external stress and activate the Toll-like receptor 4（TLR4）/NF-κB signaling pathway,resulting in the increase of the expression of inflammatory factors such as tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）and interleukin-8（IL-8）,eventually leading to the body＇s inflammatory response.GABA can reduce the damage by regulating the expres-sion of the corresponding inflammatory cytokines to the organism when the inflammatory reaction occurs in the body.This article provides a brief overview of the physiological effect of GABA,the types of GABA receptors,and the function of GABA in the inflammatory response to the body,analyzes the effect of GABA on inflammatory response in the body and its relationship with LPSinduced inflammatory response,which provide a theoretical basis for the clinical use of GABA in the treatment of inflammatory response.