新型芳香酰腙类席夫碱化合物的合成及其生物活性研究

Study on Synthesis and Biological Activities of New Aromatic Acylhydrazone Compounds

以对氯苯甲酸、甲醇、水合肼及氯代苯甲醛为原料,设计合成了邻氯苯甲醛对氯苯甲酰腙、对氯苯甲醛对氯苯甲酰腙和2,4-二氯苯甲醛对氯苯甲酰腙。利用元素分析、核磁共振氢谱及红外光谱对目标化合物进行了结构表征。以菜粉蝶5龄幼虫为试虫,研究3个目标化合物的生物活性。结果表明,合成的3个芳香酰腙类席夫碱化合物都具有一定的杀虫活性,其中,尤以2,4-二氯苯甲醛对氯苯甲酰腙的触杀活性和胃毒活性最强。

Taking p-chlorobenzoic acid,methanol,hydrazine hydrate and chlorinated benzaldehyde as materials,three new aromatic acylhydrazone schiff base compounds,namely o-chlorobenzaldehyde p-chlorobenzoyl hydrazone,p-chlorobenzaldehyde p-chlorobenzoyl hydrazone and 2,4-chlorobenzaldehyde p-chlorobenzoyl hydrazone were designed and synthesized. The structures of target molecules were confirmed by elemental analysis,H1 NMR and the infrared spectrum. Taking 5 instar larvae of Pieris rapae as test insects,the insecticidal activities of target compounds were tested in lab. The results showed that three aromatic acylhydrazone schiff base compounds had insecticidal activities against 5 instar larvae of P. rapae. Among three target compounds,2,4-chlorobenzaldehyde p-chlorobenzoyl hydrazone showed the strongest contact toxicity and stomach toxicity.