1-(2-(苄基硫代)-5-氯噻吩-3-基)乙酮的合成研究及产品表征

Synthesis and characterization of 1-(2-(benzylthio)-5-chlorothiophen-3-yl)ethanone

利用噻吩、浓盐酸和双氧水为起始原料,经过氯代反应、傅克酰基化反应和亲核加成反应合成了目标产物。考察了反应物配比、催化剂和反应时间等影响反应收率的主要因素,得到了合成目标化合物的较优反应条件。实验结果表明,该反应条件温和,后处理简单,安全系数高,并且目标产物的总收率为64.7%。利用IR、~1 H NMR和LC-MS对产物的结构进行了表征。

Using thiophene,concentrated hydrochloric acid and hydrogen peroxide as starting materials,1-（2-（benzylthio）-5-chlorothiophen-3-yl）ethanone was synthesized through chlorination reaction,Friedel-Crafts reaction and nucleophilic addition reaction.The optimal conditions for the synthesis of the target compounds were obtained by investigation of the main factors,such as the ratio of the reactants,the catalyst and the reaction time.The results show that the reaction conditions are mild,the post-treatment is simple,the safety factor is high,and the total yield of the target product is64.7%.The structure of the product was characterized by IR,1 H NMR and LC-MS.