血必净注射液辅助治疗多器官功能障碍综合征的效果及其对凝血功能的影响

Efficacy of Xuebijing Injection as adjuvant therapy for multiple organ dysfunction syndrome and its effect on patients' coagulation function

目的观察血必净注射液辅助治疗多器官功能障碍综合征(MODS)的效果及其对患者凝血功能的影响。方法将MODS患者64例随机分为对照组和治疗组,每组32例。两组患者均给予常规抗感染、对症支持等治疗,治疗组加用血必净注射液静脉滴注,疗程7 d。比较两组血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血浆纤维蛋白原(FIB)及ICU住院时间、呼吸机使用时间、抗生素使用时间、急性生理学和慢性健康状况评分(APACHEⅡ)、出院30 d时的累计死亡率。结果治疗组患者呼吸机使用时间、ICU住院时间、抗生素使用时间均短于对照组患者(均P<0.05);治疗后,两组患者的PT、APTT、TT及FIB均改善,并且治疗组改善效果好于对照组(P<0.05);治疗组出院30 d累积死亡率低于对照组(P<0.05)。结论血必净注射液可有效改善MODS患者的凝血功能,缩短呼吸机使用时间、ICU住院时间及抗生素使用时间,降低患者的近期死亡率。

Objective To observe the efficacy of Xuebijing Injection as adjuvant therapy for multiple organ dysfunction syndrome（MODS） and its effect on patients′ coagulation function. Methods Sixty-four MODS patients were randomly divided into control group（32 cases） and treatment group（32 cases）.Both groups were given anti-infection therapy,symptomatic supportive treatment and other conventional therapies,and the treatment group received intravenous drip of Xuebijing Injection.The treatment lasted for 7 days in both groups.And the indices of the two groups were compared,including prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（FIB）,ICU stay,duration of ventilator use,duration of antibiotic administration,Acute Physiology and Chronic Health Evaluation Ⅱ（APACHE Ⅱ） score,and cumulative mortality within 30 days after discharge. Results The duration of ventilator use,ICU stay,and duration of antibiotic administration in the treatment group were lower than those in the control group（all P 〈0.05）; after treatment,PT,APTT,TT and FIB were improved in both groups,and the improvement of the four indices in the treatment group was superior to that in the control group（ P 〈0.05）.The cumulative mortality within 30 days after discharge in the treatment group was lower than that in the control group（ P 〈0.05）. Conclusion Xuebijing Injection can effectively improve the coagulation function of patients with MODS,shorten the duration of ventilator use,ICU stay,and duration antibiotic administration,and reduce the patients′ short-term mortality .