M2丙酮酸激酶对炎症性肠病诊断价值的Meta分析

Diagnostic value of M2 pyruvate kinase for inflammatory bowel disease:a Meta-analysis

目的系统评价M2丙酮酸激酶(M2-PK)在炎症性肠病(IBD)诊断中的临床价值。方法计算机检索Pub Med、EMbase、Web of Science、Cochrane图书馆、中国期刊全文数据库、万方数字化期刊全文数据库中有关M2PK对IBD诊断价值的研究。筛选并对纳入文献进行质量评价,采用Meta-Disc 1.40软件对数据进行Meta分析。结果共纳入10篇文献,其中IBD组518例,对照组544例。Meta分析分析结果显示,M2-PK诊断IBD的汇总灵敏度为0.79,特异度为0.73,综合受试者工作特征(SROC)曲线下面积为0.8581,Q*为0.79889;M2-PK诊断溃疡性结肠炎的SROC曲线下面积为0.8755,Q*为0.8060;M2-PK诊断克罗恩病亚的灵敏度为0.83,特异度为0.67,SROC曲线下面积为0.8637,Q*为0.7943。结论 M2-PK对诊断IBD有较高灵敏度和特异度,可用于临床辅助诊断IBD。

Objective To systemically evaluate the clinical value of M2 pyruvate kinase（ M2-PK） in the diagnosis of inflammatory bowel disease（ IBD）. Methods A computer retrieval was performed in the databases of Pub Med,EMbase,Web of Science,Cochrane Library,CNKI database and Wan Fang database for the study on the diagnostic value of M2-PK for IBD. A quality assessment was conducted in the selected literatures. Meta-Disc 1. 40 software was applied to a Meta-analysis. Results A total of 10 studies were included,involving518 IBD patients and 504 controls. The results of the Meta-analysis showed that the combined sensitivity of M2-PK for diagnosing IBD was0. 79,the specificity was 0. 73,the area under the summary receiver operating characteristic（ SROC） curve was 0. 8581,and the Q＊was0. 79889. The area under the SROC curve of M2-PK for diagnosing ulcerative colitis was 0. 8755,and the Q＊was 0. 8060. The sensitivity,specificity,area under the SROC curve and the Q＊of M2-PK for diagnosing Crohn＇s disease were 0. 83,0. 67,0. 8637 and 0. 7943 respectively.Conclusion M2-PK has high sensitivity and specificity in the diagnosis of IBD,and can be used in the adjuvant clinical diagnosis of IBD.