高血压对阿尔茨海默病患者血浆可溶性CD40及配体水平的影响

Effect of hypertension on plasma soluble CD40 and its ligand level in patients with Alzheimer's disease

目的:探讨高血压对阿尔茨海默病(alzheimer’s disease,AD)患者血浆可溶性CD40(s CD40)及其配体(s CD40L)水平的影响。方法:随机抽取伴高血压的AD患者40例(高血压组)、不伴高血压的AD患者45例(非高血压组)、健康体检正常人群40名(对照组),分别通过MMSE量表、酶联免疫吸附法(ELISA)测定评价各组认知功能、s CD40及s CD40L水平,并经由Spearman相关性分析MMSE评分与s CD40及s CD40L的关系。结果:3组MMSE评分[(10.23±5.47)vs.(14.64±2.39)vs.(27.05±1.86)]分、血浆s CD40[(132.65±10.02)vs.(122.38±12.54)vs.(70.32±10.00)]pg/m L、s CD40L[(614.73±52.64)vs.(535.38±46.92)vs.(164.35±25.49)]pg/m L,组间比较差异均有统计学意义(P<0.05);高血压组MMSE评分与血浆s CD40、s CD40L成负相关(r=-0.823、-0.653,P<0.05),非高血压组MMSE评分也与血浆s CD40、s CD40L成负相关(r=-0.567、-0.519,P<0.05)。结论:AD患者中血浆s CD40及s CD40L高表达,其表达与MMSE评分相关;高血压显著增加AD患者血浆s CD40、s CD40L水平,为AD发生危险因素。

Objective： To investigate the effect of hypertension on plasma soluble CD40（ s CD40） and its ligand（ s CD40 L） levels in patients with alzheimer＇s disease（ AD）. Methods： 40 cases of AD patients with hypertension were selected as hypertension group,45 cases of AD patients without hypertension were selected as non-hypertension group,and 40 cases of healthy subjects were selected as control group randomly. The cognitive function,s CD40 and s CD40 L levels were determined by MMSE scale and enzyme linked immunosorbent assay（ ELISA）. The relationship between MMSE score and s CD40 and s CD40 L was analyzed by Spearman correlation analysis. Results： There were significant differences among the three groups in MMSE scores [（ 10. 23 ± 5. 47） vs.（ 14. 64 ± 2. 39） vs.（ 27. 05 ± 1. 86） ],plasma s CD40 [（ 132. 65 ± 10. 02） vs.（ 122. 38 ± 12. 54） vs.（ 70. 32 ± 10. 00） ]pg/Ml,and s CD40 L [（ 614. 73± 52. 64） vs.（ 535. 38 ± 46. 92） vs.（ 164. 35 ± 25. 49] pg/m L（ P 0. 05）. In the hypertension group,MMSE score was negatively correlated with plasma s CD40 and s CD40 L（ r =-0. 823,-0. 653,P〈0. 05）,which was the same in the non-hypertension group（ r =-0. 567,-0. 519,P〈0. 05）. Conclusion： The expression of s CD40 and s CD40 L is high in plasma of patients with AD,and it is significantly correlated MMSE score. Hypertension will significantly increase the levels of plasma s CD40 and s CD40 L in patients with AD,and it is the risk factors for AD.