高流量鼻导管湿化氧疗联合人免疫球蛋白治疗新生儿感染性肺炎的疗效及安全性分析

Efficacy and safety analysis of nasal high flow nasal cannulae oxygen therapy combined with IVIG in the treatment of neonatal infectious pneumonia

目的:探讨高流量鼻导管湿化氧疗(high flow nasal cannulae oxygen therapy,HFNC)联合人免疫球蛋白(IVIG)治疗新生儿感染性肺炎(neonatal infectious pneumonia,NIP)的疗效及安全性。方法:收集100例NIP患者,随机数表法分为对照组和观察组,每组各50例。常规抗感染治疗基础上,对照组给予HFNC辅助治疗,观察组给予HFNC联合IVIG治疗。观察两组NIP患儿血气分析指标、免疫学指标变化,评估临床治疗效果及安全性。结果:两组治疗后Pa O2明显提高,Pa CO2显著下降(P<0.05),但组间相较差异无统计学意义(P>0.05);两组治疗后观察组血清Ig G及亚类Ig G1、Ig G2、Ig G3、Ig G4表达均有显著上升(P<0.05),观察组治疗后血清Ig G、Ig G2、Ig G4表达较对照组高,差异具有统计学意义(P<0.05);观察组治疗总有效率96.00%显著高于对照组84.00%(P<0.05);两组不良反应发生率相较无统计学意义(P>0.05)。结论:HFNC联合IVIG能有效改善NIP患儿血气分析和免疫指标,安全性高。

Objective： To investigate the efficacy and safety of nasal high flow nasal cannulae oxygen therapy（ HFNC） combined with IVIG in the treatment of neonatal infectious pneumonia（ NIP）. Methods： 100 cases of NIP were collected. According to the order of admission,patients were randomly divided into the control group and the observation group,each group had 50 cases. On the basis of routine anti infection treatment,the control group was given HFNC adjuvant treatment,while the observation group was treated with HFNC combined with IVIG. The changes of blood gas analysis and immunological indexes in the two groups were observed,and the clinical efficacy and safety were evaluated. Results： After treatment,Pa O2 increased significantly and Pa CO2 decreased significantly in the two groups（ P〈0. 05）,but there was no significant difference between the groups（ P〈0. 05）. The expression of Ig G and subclass Ig G1,Ig G2,g G3 and Ig G4 in the two groups increased significantly after treatment（ P〈0. 05）,and the serum Ig G,Ig G2,and Ig G4 expressions were higher in the observation group than those in the control group,the differences were statistically significant（ P〈0. 05）.The total effective rate of treatment in the observation group was 96%,significantly higher than that of the control group（ 84%）（ P〈0. 05）,and the adverse reactions of the two groups were not statistically significant（ P〈0. 05）. Conclusion： HFNC combined with IVIG can effectively improve the blood gas analysis and immune indexes of NIP neonates,and the clinical efficacy and safety are significant.