预防应用甲氧氯普胺注射液对ST段抬高型心肌梗死急诊PCI术的疗效观察

Preventive effect of metoclopramide hydrochloride injection on emergent PCI in patients with ST elevation myocardial infarction

目的:观察并分析预防性应用盐酸甲氧氯普胺注射液对ST段抬高型心肌梗死(STEMI)患者急诊PCI术中及术后呕吐的效果。方法:收集STEMI患者行急诊PCI病例134例,随机分为给药组和空白组,每组各67例。其中给药组给予静脉注射10 mg(1.0 m L)甲氧氯普胺注射液,空白组给予等量的0.9%生理盐水,记录并分析术后24 h内两组患者的PONV事件发生频率以及严重程度,同时观察术中知晓以及椎体外系症状等不良反应情况。结果:与空白相比,术后给药组患者PONV的发生频率显著降低(P<0.05);术后给药组的PONV的严重程度与空白组相比没有差异(P>0.05),无椎体外系症状等不良反应的发生。结论:预防应用甲氧氯普胺注射液可以降低STEMI患者急诊PCI术的PONV发生率,值得在急诊PCI术前推广应用。

Objective： To observe and analyze the effect of prophylactic application of metoclopramide hydrochloride injection on patients with ST elevation myocardial infarction（ STEMI） during and after emergency PCI. Methods： Our research team collected 134 cases of STEMI,and randomly divided into treatment group and control group with each group 67 cases. The treatment group treated with metoclopramide hydrochloride（ intravenous injection,10 mg）,and the control group treated with nomal saline. The frequency and severity of PONV events within 24 h after surgery in two groups were recorded and analyzed,and the adverse reactions in the intraoperative awareness and the symptoms of extrapyramidal were observed. Results： Compared with the control group,the occurrence rate of PONV within 24 h were significantly decreased in treatment group（ P〈0. 05）. There was no difference of the severity of PONV within 24 h after surgery between the two groups（ P〉0. 05）,there was no occurrence of adverse reactions such as the symptoms of extrapyramidal.Conclusion： Prevention of metoclopramide hydrochloride injection can reduce the incidence of PONV in STEMI patients undergoing emergency PCI,and is worthy of promotion before emergency PCI.