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加味苓桂术甘汤联合盐酸多奈哌齐治疗血管性痴呆的临床效果观察 被引量:5

Clinical observation of Jiawei linggui zhugan decoction Combined with donepezil in treatment of vascular dementia
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摘要 目的观察加味苓桂术甘汤联合盐酸多奈哌齐治疗血管性痴呆的临床效果及安全性。方法将100例血管性痴呆患者随机分为观察组和对照组,每组50例。对照组予盐酸多奈哌齐治疗,观察组予加味苓桂术甘汤联合盐酸多奈哌齐治疗,观察比较2组临床疗效,以简易智力状态检查量表(MMSE)评价患者认知能力,以适应行为评定量表(ADL)评价患者日常生活能力,比较2组治疗前后MMSE、ADL量表评分,统计2组治疗期间不良反应发生率。结果观察组显效率为40. 00%、总有效率为78. 00%,高于对照组的10. 00%、54. 00%(P <0. 01或P <0. 05);治疗后,2组MMSE、ADL评分均高于治疗前,且观察组治疗后MMSE、ADL评分高于对照组(P <0. 01或P <0. 05); 2组不良反应发生率比较差异无统计学意义(P> 0. 05)。结论加味苓桂术甘汤联合盐酸多奈哌齐治疗血管性痴呆效果显著,优于盐酸多奈哌齐单药治疗。 Objective To observe the clinical effect of Jiawei linggui zhugan decoction combined with donepezil in the treatment of vascular dementia. Methods 100 patients with vascular dementia were randomly divided into the observation group and the control group, 50 cases in each group. The control group was treated with donepezil, and the observation group was treated with Jiawei linggui zhugan decoction combined with donepezil. The curative effect of the 2 groups was observed and compared. The patients' cognitive ability was evaluated by MMSE, and the patients' daily life ability was evaluated with ADL. The MMSE scores and ADL scores of the 2 groups were compared before and after treatment, and the incidence of adverse re- actions in the 2 groups was statistically analyzed. Results The excellence rate of the observation group was 40.00%, and the total effective rate was 78.00%, which was higher than 10.00% and 54.00% of the control group (P 〈 0.01 or P 〈 0.05 ). The MMSE scores and ADL scores of the 2 groups after treatment were all higher than those before treatment, and the scores of the observation group were higher than those of the control group (P 〈 0.01 or P 〈 0.05 ). There was no significant difference in the incidence of adverse reactions between the 2 groups (P 〉 0.05). Conclusion Jiawei linggui zhugan decoction com- bined with donepezil is effective in treating vascular dementia, which is superior to donepezil in monotherapy.
作者 蒋颖 韩景波 麦丽莎 丘彬彬 苏博慧 JIANG Ying;HAN Jing-bo;MAI Li-sha(Department of Geriatrics,The First Affiliated Hospital of Guangxi University of Chinaese Medicine,Nanning 537000,China)
出处 《临床合理用药杂志》 2018年第23期5-6,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 苓桂术甘汤 盐酸多奈哌齐 血管性痴呆 治疗 Linggui Zhugan Decoction Donepezil Vascular dementia Treatment
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