祛痹汤治疗膝骨关节炎的临床效果及其对血清炎性因子水平的影响研究

Clinical effect of Qu Bi Decoction on knee osteoarthritis and its effect on serum inflammatory factors

目的探讨祛痹汤治疗膝骨关节炎(KOA)的临床效果及其对血清炎性因子水平的影响。方法选取医院收治的KOA患者92例,随机分为观察组和对照组,每组46例。对照组予美洛昔康治疗,观察组予祛痹汤治疗,比较2组治疗效果与治疗前后炎性因子水平变化。结果观察组总有效率为95. 7%,高于对照组的76. 1%(P <0. 01);治疗前2组炎性因子水平比较差异无统计学意义(P> 0. 05),治疗后观察组TGF-β、IGF-I高于对照组,IL-1β低于对照组(P <0. 01)。结论祛痹汤治疗膝骨关节炎,可有效改善患者临床症状、关节功能及炎性因子水平,安全可靠,值得临床推广应用。

Objective To investigate the clinical effect of Qu Bi Decoction on knee osteoarthritis and its effect on serum inflammatory factors. Methods 92 patients with KOA in our hospital were selected and randomly divided into observation group and control group, 46 cases in each group. The control group was treated with meloxicam, and the observation group was treated with Qu Bi decoction. The therapeutic effect and the level of inflammatory factors before and after treatment were compared between the 2 groups. Results The total effective rate of the observation group was 95.7%, which was significantly higher than that of the control group （76.1% ） （ P 〈 0. 01 ）. There was no significant difference in the levels of inflammatory factors between the 2 groups before treatment （ P 〉 0.05 ）. After treatment, the TGF-β and IGF-1 levels of the observation group were higher than those of the control group, while the IL-1β level was lower than that of the control group （ P 〈 0.05 ）. Conclusion Qu Bi decoction can effectively improve the clinical symptoms, joint function and inflammatory factors in patients with knee osteoarthritis. It is safe and reliable, and is worthy of clinical application.