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鲑鱼降钙素联合塞来昔布在老年全髋置换术围手术期疼痛中的治疗效果 被引量:3

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摘要 目的观察鲑鱼降钙素联合塞来昔布治疗老年全髋置换术围手期疼痛的效果。方法选择医院行全髋置换术的老年患者75例,随机分为A、B、C组,每组25例。3组均进行全髋关节置换手术,在此基础上A组采用鲑鱼降钙素辅助治疗,B组采用塞来昔布治疗,C组联合应用鲑鱼降钙素和塞来昔布治疗。观察比较3组术后24 h、48 h的镇痛效果,术后患肢主动行直腿抬高30°时间、主动外展45°时间,用药期间药物不良反应发生情况。结果C组术后24 h疼痛VAS评分为(3. 17±0. 31)分、术后48 h VAS评分为(2. 68±0. 26)分,均低于A组、B组(P <0. 01); C组主动直腿抬高30°时间为(1. 83±0. 74) d、主动外展45°时间为(2. 93±1. 15) d,均早于A组、B组(P <0. 01);用药期间,3组间不良反应发生率比较差异无统计学意义(P> 0. 05)。结论与单一用药相比,鲑鱼降钙素联合塞来昔布应用于老年全髋置换术围术期具有较好的镇痛效果,利于髋关节功能恢复,且不会增加不良反应,值得推广应用。
作者 程绍君
出处 《临床合理用药杂志》 2018年第23期56-57,共2页 Chinese Journal of Clinical Rational Drug Use
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