摘要
精准医学在结核病领域中的应用尚处于起步阶段,结核病的精准治疗离不开快速准确的诊断、有效的抗结核药物、新型前沿技术的综合应用。近年来,结核病精准治疗主要聚焦于耐药结核病、宿主导向治疗及纳米靶向治疗,并取得了一定的成果,为结核病,特别是耐药结核病的治疗提供了重要手段。在未来,新药研发和新兴技术的应用是结核病精准治疗的关注重点,需要逐步开展相关的临床试验研究,客观评价其应用价值和前景。
The application of precision medicine in the field of tuberculosis is still in its infancy. The precision medicine of tuberculosis cannot be separated from the rapid and accurate diagnosis, the effective anti-tuberculosis drugs,and the comprehensive application of new cutting-edge technologies. In recent years, the precision medicine of tuberculosis has focused on drug-resistant tuberculosis, host-directed therapy and nano-targeted therapy, which has achieved certain results, providing an important mean for the treatment of tuberculosis, especially for the drug-resistant tuberculosis. In the future, the development of new drugs and the application of emerging technologies are the focus of precision medicine of tuberculosis. It is necessary to gradually carry out relevant clinical trial research and objectively evaluate its application value and prospects.
作者
顾瑾
唐神结
GU Jin;TANG Shenjie(Clinical and Research Center of Tuberculosis,Shanghai Key Lab of Tuberculosis,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,P.R.China;Multidisciplinary Diagnosis and Treatment Center,Beijing Chest Hospital,Capital Medical University,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,P.R.China)
出处
《华西医学》
CAS
2018年第8期930-934,共5页
West China Medical Journal
基金
"十二五"国家科技重大专项(2015ZX10003001)
关键词
结核
精准治疗
耐药结核病
宿主导向治疗
纳米靶向治疗
Tuberculosis
Precision medicine
Drug-resistant tuberculosis
Host-directed therapy
Nano-targeted therapy
