OX40／OX40L在诱导移植免疫耐受中的研究进展

Research progress in OX40/OX40L-induced transplantation tolerance

OX40（CD134）是T细胞表面的一种共刺激分子，其与抗原提呈细胞（antigen presentingcell，APC）表面的OX40L（CD252）结合，参与T细胞活化第二信号的传导，对T细胞的增殖、分化、存活、迁移具有重要的意义。通过阻断OX40／OX40L共刺激途径理论上可抑制免疫功能，在诱导T细胞克隆无能进而诱导免疫耐受中存在着不可忽视的潜能。本文就OX40／OX40L在诱导移植免疫耐受中的研究进展做一综述。

OX40 （CD134） is a costimulatory molecule on the surface of T cells. It binds to OX40L （CD252） that is expressed on the surface of antigen presenting cells （APC） and participates in the transmission of the second signal of T cell activation, indicating that it is of great importance to the proliferation, differentiation, survival and migration of T ceils. In theory, blocking the OX40/OX40L costimulatory pathway can suppress immune response and induce immune tolerance. In this review, we reviewed the research progress in OX40/OX40L-induced transplantation tolerance.