慢性肾脏病Ⅲ-Ⅴ期患者发生贫血的相关因素分析

The incidence of anemia and the analysis of its related factors in patients with chronic kidney disease at stage Ⅲ-Ⅴ

目的探讨慢性肾脏病Ⅲ-Ⅴ期患者贫血的发生及相关因素,为有效降低慢性肾脏病Ⅲ-Ⅴ患者贫血的发生率提供临床依据。方法回顾分析2015年5月至2017年4月收治的146例慢性肾脏病Ⅲ-Ⅴ期患者临床资料,采用单因素及多因素Logistic回归分析,对可能影响慢性肾脏病Ⅲ-Ⅴ期患者发生贫血的各因素进行分析。结果146例慢性肾脏病Ⅲ-Ⅴ期患者中,发生贫血者76例,发生率为52.1%,严重程度方面,轻度贫血占9.2%,中度贫血占35.5%,重度贫血占36.8%,极重度贫血占18.4%;单因素分析,血磷水平、血钙水平、血铁水平、维生素D含量、糖尿病与慢性肾脏病Ⅲ-Ⅴ期患者并发贫血有关(P<0.05);多因素Logistic回归分析,血磷水平偏高、血钙水平偏低、血铁水平偏低、维生素D含量偏低4个危险因素为影响慢性肾脏病Ⅲ-Ⅴ期患者发生贫血的独立危险因素(P<0.05)。结论血磷水平偏高、血钙水平偏低、血铁水平偏低、维生素D含量偏低是慢性肾脏病Ⅲ-Ⅴ期患者贫血的独立危险因素,需要引起临床工作者的重视。

Objective To investigate the incidence of anemia and its related factors in patients with chronic kidney disease so as to reduce the incidence of anemia in patients with chronic kidney disease at stage Ⅲ-Ⅴ. Methods The clinical data of 146 patients with chronic renal disease at stage Ⅲ-Ⅴ treated in our hospital from May 2015 to April 2017 were analyzed retrospectively, and the single factor and multiple factor Logistic regression analysis were used to analyze factors affecting anemia in patients with chronic kidney disease at stage Ⅲ-Ⅴ. Results Of the 146 patients with chronic kidney disease,anemia occurred in 76 cases, with the incidence of anemia rate of 52.1%. In terms of severity, mild anemia accounted for9.2%, moderate anemia accounted for 35.5%, severe anemia accounted for 36.8% and extremely severe anemia accounted for18.4%. Single factor analysis showed that serum phosphorus levels, serum calcium levels, blood iron levels, content of vitamin D and diabetes mellitus were associated with anemia in patients with chronic kidney disease at stage Ⅲ-Ⅴ（P〈0.05）.The multiple factor Logistic regression analysis showed that the high level of blood phosphorus, low level of blood calcium,low level of blood iron and low content of vitamin D were the independent risk factors that affected anemia in patients with chronic kidney disease at stage Ⅲ-Ⅴ（P〈0.05）. Conclusion Factors of the high level of blood phosphorus, low level of blood calcium, low level of blood iron and low content of vitamin D were the independent risk factors that affected anemia in patients with chronic kidney disease at stage Ⅲ-Ⅴ, which should be paid more attention by clinical workers.