摘要
羟氯喹作为传统抗疟疾药物,目前主要用于风湿免疫性疾病的治疗,并且还具有抗肿瘤活性,其作用机制包括:影响溶酶体功能,抑制细胞自噬,调节免疫,影响相关蛋白及通路,抑制炎症反应,影响内涵体功能,通过线粒体途径诱导细胞凋亡以及化疗增敏等。本文拟对羟氯喹的抗肿瘤机制及其抗肿瘤临床试验进行综述,以期为进一步的研发和应用奠定基础。
As a traditional anti-malaria drug,hydroxychloroquine is currently used for the treatment of rheumatic autoimmune diseases and it also has antitumor activity and the mechanisms include affecting lysosomal function,inhibiting autophagy,regulating immune,affecting related proteins and pathways,inhibiting inflammatory,influencing the function of endosome,inducing apoptosis through mitochondria pathway and sensitizing chemotherapy. In this paper, the anti-tumor mechanisms of hydroxychloroquine and its clinical trials are reviewed in order to lay a foundation for further research and application of hydroxychloroquine.
作者
韩丽珠
石慧
肖洪涛
陈晓玲
HAN Li-zhu;SHI Hui;XIAO Hong-tao;CHEN Xiao-ling(Department of pharmacy,Affiliated Hospital of University of Electronic Science and Technology of China,Sichuan Academy of Medical Sciences and Sichuan Provincial People＇s Hospital,Personalized Drug Therapy Key Laboratory of Sichuan Province,Chengdu 610072,China;School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China;Department of Gynecology,Wuhan Hospital of Traditional Chinese Medicine,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2018年第16期2022-2025,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家临床药学重点专科建设课题资助项目(30305030698)
四川省卫生厅基金资助项目(100491
120111
17Z0038)
四川省科技厅基金资助项目(2014FZ0103
2015JQO027
2015ZR0160)
四川省人民医院青年基金资助项目(30305030606
30305030859)
关键词
羟氯喹
肿瘤
机制
临床试验
hydroxychloroquine
cancer
mechanism
clinical trial
