基于关联规则和复杂系统熵聚类的人工流产术后宫腔粘连用药规律研究

Analysis on Medication Rule in Herbal Prescriptions for Intrauterine Adhesious after Induced Abortion

目的:研究防治人工流产术后宫腔粘连的中药内服处方的用药规律。方法:通过中国知网、重庆维普、万方、中国生物医学文献数据库搜集1979年至2017年6月15日治疗术后宫腔粘连的中药处方,利用TCM ISS中医传承辅助平台软件提炼分析得出处方中各药物的使用频次、四气五味归经、归类及药物间的关联规则等。结果:提炼分析223个中药处方,得出使用频次较高的中药有当归、红花、川芎、骨碎补、续断、熟地黄、桃仁、赤芍等。温、平、凉是药物四气的主要分布,苦、甘、辛为五味的主要分布,肝、脾、肾、心为归经的主要分布,伞形科、毛茛科、菊科为归类的主要分布。当归、熟地黄、川芎、赤芍、桃仁、红花等均为临床治疗人工流产术后宫腔粘连最常用的中药。结论:中药治疗术后宫腔粘连以补血活血,化瘀散结为主要治法,常用处方为桃红四物汤,关键药物组合是当归与红花,处方用药应以"通散胞宫之瘀结,补养胞脉之血亏"为则。

Objective： To analyze the medication rule in herbal prescriptions for intrauterine adhesious after induced abortion. Methods： Herbal prescriptions for intrauterine adhesious after induced abortion were searched from Chinese National Knowledge Infrastructure, VIP database, Wanfang database and Chinese Biomedical Database, from 1979 to June 15th, 2017. We used Chinese medicine inheritance support system （TCMISS） to an- alyze the frequency, four natures, five flavors, meridian entry, plant classification of drugs, and the association rules between drugs. Results： Based on the analysis of 223 herbal prescriptions, herbs used with high frequency were Danggui （Radix Angelicae Sinensis）, Honghua （Flos Carthami）, Chuanxiong （Rhizoma Chuanxiong）, Gusuibu （Drynaria Rhizome）, Xuduan （radix dipsaci）, Shudihuang （Radix Rehmanniae Praeparata）, Taoren （Semen Persicae） and Chishao （Radix Paeoniae Rubra）, et al. Four natures of drugs were mainly consist of warmth, neutral and coolness. Five flavors of drugs were mainly consist of bitter, sweet and pungent. Meridian entrys were mainly consist of liver, spleen, kidney and heart. Plant classification of drugs mainly consist of Apiaceae, Ranuncu- laceae and Asteraceae. Danggui （Radix Angelicae Sinensis）, Shudihuang （Radix Rehmanniae Praeparata）, Chuanx- iong （Rhizoma Chuanxiong）, Chishao （Radix Paeoniae Rubra）, Taoren （Semen Persicae） and Honghua （Flos Cartha- mi）, et al, were the most commonly used traditional Chinese Medicine for intrauterine adhesious after induced abortion. Conclusion： The main principles of treatment for intrauterine adhesious after induced abortion is en- riching and promoting blood circulation for removing blood stasis and eliminating stagnation. The most commonly used traditional Chinese medicine prescription＇ was Taohong Siwu Decoction （桃红四物汤）. The key drug combi- nation are Danggui （Radix Angelicae Sinensis） and Honghua （Flos Carthami）. We emphasize the medication prin- ciple that the medicine should dissipate the blood stasis of uterus, replenish blood of the vessels of the uterus.