不同中医体质健康人群的唾液Cor及SIgA比较研究

Comparative Study of Salivary Cortisol and SIgA from Healthy Subjects in Different Constitution of Traditional Chinese Medicine

目的:探讨不同体质健康人群中唾液Cor(salivary cortisol,SC)、分泌型免疫球蛋白A(secretory immunoglobulins A,SIgA)的含量分布及这两种生物指标间的关系。方法:纳入270例健康体检者。按照其体质特点分为9种体质,每组各30例,分别研究这9组人群中SC和SIgA的分布规律。结果:9组体质人群中各组的SC和SIgA含量分布均有一定区间范围,SC和SIgA呈正相关,r=0.65,P<0.05。结论:不同体质的健康人群中SC和SIgA分布有一定规律性,且SC和SIgA存在一定程度的相关,这两种指标具有作为体质评定和干预备选生物指标的潜能。

Objective： To investigate the concentration of salivary cortisol （SC） and secretory immunoglobulins A （SIgA） from healthy subjects in different constitution of Traditional Chinese Medicine and the correlation of the two biomarkers. Methods： Totally 270 eligible healthy subjects were included and divided into 9 groups accord- ing to their constitutional characteristics with 30 cases in each group. Concentration of SC and SIgA in each group was measured and compared. Results： Specific ranges of values of concentration of SC and SIgA were found in all the 9 groups; The comparison of each two groups mostly showed statistical difference （P〈O.05）, and the Pearson correlation coefficient was 0.65 between SC and SIgA （P〈0.05）. Conclusion： Specific law of distri- bution existed in the concentration of SC and SIgA from healthy subjects in different constitution of Traditional Chinese Medicine and the concentration of SC correlated with SIgA in some extent. The two biomarks had the potential to act as alternative biomarks of constitutional iudgement and interventions.