Ag_2S纳米晶的制备及其近红外光热治疗应用

Preparation of Ag_2S Nanocrystals for NIR Photothermal Therapy Application

光热治疗是近年来受到广泛关注的一种低副作用的癌症治疗方法,治疗中使用的纳米光热剂的制备和性能是决定光热治疗效应的关键因素。本研究采用热解和表面配体置换相结合的方法制备得到二氢硫辛酸(DHLA)修饰的Ag_2S纳米晶材料,这种材料具有良好的水溶性、光热稳定性和生物相容性。研究结果显示浓度大于40μg/mL的Ag_2S纳米晶在波长为980 nm、功率密度为5 W/cm^2的红外激光照射下对宫颈癌细胞具有明显的杀伤效果,且光热稳定性良好。Ag_2S纳米晶的光热效应与其良好的荧光成像功能相结合,可实现光热治疗的可视化和精准化。

Photothermal therapy（PTT） is a promising cancer treatment with both high effectiveness and low side effects. It is very important that the advancement of the NIR photothermal cancer therapy is dependent on the development of photothermal agents. Herein, this study developed hydrophilic DHLA-Ag2S nanocrystals as a new photothermal agent, which were synthesized by combining a thermal decomposition and ligand exchange route. The as-prepared Ag2S nanocrystals appear good water solubility, photo thermal stability and biocompatibility. Under irradiation of 980 nm laser with a power density of 5 W/cm^2, He La cancer cells in vitro can be efficiently killed by photothermal effects of the Ag2S nanocrystals（40 μg/mL）. The photothermal effect of Ag2S nanocrystals and its good fluorescence imaging function can realize the visualization and precision of photothermal therapy.