非共价键胶束方法与原理的拓展与应用

Further Expansions and Applications of the Principles and Methodology of Non-covalent Connected Micelles

20世纪末,江明等在其有关大分子络合的研究基础上,通过将大分子间相互作用局域化,成功地利用大分子间的络合来驱动结构规整组装体的形成.这一思想和方法通过不断地拓展和深化,形成了大分子自组装的新路线,获得了一系列具有新颖结构与功能的核壳间为非共价键连接的聚合物胶束(non-covalently connected micelles,NCCM).本综述将对近年来我们在非共价键胶束方法与原理的拓展与应用方面取得的成果作一总结.内容包括:为NCCM的形成引入新的驱动力,并同时赋予NCCM新的性质与功能;将NCCM的形成原理应用于生物大分子的自组装,发展出了全绿色的大分子自组装路线;运用将相互作用局域化的基本思想,将嵌段共聚物的化学交联反应局域化,发展出化学交联诱导嵌段共聚物胶束化的新方法.

At the end of the last century, Professor Jiang Ming et al. succeeded in fabricating regular nanostructures through localizing interactions in the systems of polymer complexes. Through continuous expansion and deepening of this principle and method, a new strategy of macromolecular self-assembly was established. This review summarizes recent developments and applications of non-covalently connected micelles （NCCMs）, including： Introducing of new driving forces such as supramolecular interactions to drive the formation of NCCMs, providing the resultant NCCMs with new features and functions; Applying the principle to the self- assembly of biological macromolecules, thereby developing an entirely green route to self-assembly of macromolecules; Also, through localizing covalent crosslinking reaction of one block of a diblock copolymer, we realized micellization of the block copolymer in its common solvent induced by the crosslinking reaction, resulting in highly efficient fabrication of core-stabilized micelles as well as a new pathway for controlling the kinetics of polymer micellization, the structures and the properties of the polymeric micelles.