IL-17与结核病的研究进展

Advances in the study of the association between IL-17 and tuberculosis

白介素17(interleukin-17,IL-17)主要是由Th17细胞分泌的一种促炎症性细胞因子(cytokine,CK),其在慢性炎症疾病和抵御细胞内外病原体的免疫反应中有重要的作用。结核病(tuberculosis,TB)仍然是全球备受关注的公共卫生问题,目前有研究已经证明IL-17与结核病的免疫机制相关,在结核分枝杆菌感染的不同阶段发挥不同的作用,深入探究IL-17与结核分枝杆菌感染的免疫保护和免疫病理学的关系,对于结核病的疫苗改善设计、有效诊断和治疗都有极其深远的意义。

Interleukin 17（IL-17）is a type of proinflammatory cytokine（CK）that is mainly secreted by Th17 cells.IL-17 plays a key role in chronic inflammatory disorders as well as in host immune responses to extracellular and intracellular pathogens.Tuberculosis（TB）remains a major public health concern worldwide.Previous studies have indicated that IL-17 is associated with the mechanisms of immune evasion by Mycobacterium tuberculosis and that IL-17 plays different roles in different stages of TB.Exploring the relationship between IL-17 and immunoprotection from or the immunopathology of TB is crucial to improving the design of TB vaccines and effective diagnosis and treatment of TB.