肠道微生态与2型糖尿病关系的研究进展

Research progress on the relationship between gut microbiota and type 2 diabetes mellitus

肠道微生态是影响能量代谢的关键因素,肠道菌群参与机体代谢,其结构功能失调将影响能量平衡、糖脂代谢以及炎症反应等。研究表明,T2DM患者存在肠道菌群中度失衡,是糖代谢紊乱的重要始动因素,调整肠道菌群结构失调已作为药物干预靶点,引起了越来越多学者的关注。本文对肠道微生态变化与T2DM发生发展关系的相关研究及发展趋势进行综述。

Recent studies have found that gut microbiota is a key factor for energy metabolism.The structural dysfunction of gut microbiota would affect energy balance,glycolipid metabolism,and inflammatory.Researches showed that patients with type 2 diabetes mellitus（T2 DM）have moderate imbalance of gut microbiota,which was the important initiating factor in disturbance of glucose metabolism.Improving the structure of gut microbiota has been used as a new therapeutic target of adjusting glucose metabolic disturbance,and attracted more and more attention.Here,we would summarize and review the researches and development trend of the relationship between gut microbiota and T2 DM.