乳腺导管内原位癌浸润机制

Mechanism of ductal carcinoma in situ to invasive breast cancer

乳腺导管内原位癌被认为是浸润性导管癌的前驱病变，若未经治疗，约40％的原位癌病变可进展为浸润性癌。在乳腺导管内原位癌的浸润转化过程中，肿瘤微环境、驱动基因、信号通路和表观遗传等发挥了重要作用。深入研究乳腺导管内原位癌向浸润性癌转化的过程将有利于推动对乳腺导管内原位癌个体化的精准评估，可更好地预测乳腺导管内原位癌的预后，以期找出一个对患者最有利的综合评定标准，在过度与低度治疗问找到平衡点。

Ductal carcinoma in situ （DCIS） is a precursor of invasive ductal breast cancer, and up to 40% of these lesions will progress to invasive disease if untreated. The micro-environment, genetic aberrations, signal pathways and epigenetics play important roles during the infiltration and transformation of DCIS. Further studies of the infiltration and transformation of DCIS will promote the accurate assessment and prognosis prediction of the patients with DCIS, for finding a comprehensive evaluation standard and the balance between the over and low treatment.