利奈唑胺与替考拉宁序贯治疗革兰阳性球菌重症肺炎的疗效观察

Effect of sequential therapy of linezolid and teicoplanin for the treatment of the severe pneumonia induced by gram - positive coccus

目的探讨利奈唑胺与替考拉宁序贯治疗革兰阳性球菌重症肺炎的疗效。方法选取2014年9月至2017年8月舟山市中医院收治的革兰阳性球菌重症肺炎患者80例，首先给予利奈唑胺静脉滴注，疗程为7d，再静脉滴注替考拉宁，疗程为7d。分别对治疗前后患者的临床疗效和不良反应发生情况进行分析。结果80例患者中治愈51例（63．75％）、显效19例（23．75％）、进步8例（10．00％）、无效2例（2．5％），总有效率为87．5％；病原菌清除率为87．50％；均未出现肝肾功能损害、血小板计数下降等不良反应。结论利奈唑胺与替考拉宁序贯治疗革兰阳性球菌重症肺炎具有良好的疗效；病原菌清除率高，安全性好。

Objective To investigate the effect of sequential therapy of linezolid and teicoplanin for the treatment of the severe pneumonia induced by gram - positive coccus. Methods From September 2014 to August 2017,0 cases of severe pneumonia patients in the Traditional Chinese Medicine Hospital of Zhoushan were gram positive coccus ,tumbled to rina amine for patients treated with intravenous drip, the course of treatment was 7 days, and then intravenous drip their stead better treatment,treatment for 7 days, the clinical situation of patients before and after treatment respectively, the characteristics of signs and adverse reactions were analyzed. Results Among the 51 cases （63.75%） ,19＂cases （23.75%） ,8 cases （ 10.00% ） ,and 2 cases （2.5%） ,the total effective rate was 87.5%. In the distribution and clearance rate of pathogenic bacteria ,the bacterial clearance rate of liniazolamide and the replacement of gram - positive coccus pneumoniae was 87. 50%. There was no other adverse reaction. Conclusion Sequential therapy of linezolid and teicoplanin for the treatment of the severe pneumonia induced by gram- positive coccus has several good effects, high clearance rate of pathogenic bacteria, good security.