经鼻持续气道正压通气对睡眠呼吸暂停综合征患者睡眠、生活质量及血糖的影响

Study on sleep and blood glucose changes of patients with OSAHS before and after nasal continuous positive airway pressure ventilation

目的 探讨经鼻持续气道正压通气对睡眠呼吸暂停综合征（OSAHS）患者睡眠、生活质量及血糖的影响.方法 选择菏泽市定陶区人民医院2016年8月至2017年6月收治的OSAHS患者82例为研究对象,采用随机数字表法分为两组各41例,观察组给予经鼻持续气道正压通气,对照组则行保守治疗,比较两组干预后匹兹堡睡眠质量及生活质量评分,及两组空腹血糖及空腹胰岛素水平变化情况.结果 干预后,观察组匹兹堡睡眠质量评分为（12.3±0.9）分,低于对照组的（15.6± 1.6）分（t=11.369,P＜0.05）;生活质量评分为（56.3±2.9）分,低于对照组的（68.9±5.3）分（t=13.190,P＜0.05）.观察组空腹血糖为（5.1±0.9） mmol/L,低于对照组的（7.3±1.1）mmol/L（t =9.790,P＜0.05）;空腹胰岛素水平为（6.4±0.3）mU/L,高于对照组的（4.1 ±0.1） mU/L（t =46.000,P＜0.05）.结论 针对OSAHS患者,行经鼻持续气道正压通气治疗,能有效改善患者睡眠及生活质量,更好地调控血糖.

Objective To investigate the effect of nasal continuous positive airway pressure on sleep quality and blood glucose in patients with sleep apnea syndrome.Methods From August 2016 to June 2017,82 patients with OSAHS in the People＇s Hospital of Dingtao District were selected and divided into two groups according to the random number table,with 41cases in each group.The observation group was treated with nasal continuous positive airway pressure ventilation and the control group was treated conservatively.The sleep quality and quality of life score of Pittsburgh were compared between the two groups.The changes of fasting blood glucose and fasting insulin in the two groups were compared.Results After the intervention,the sleep quality score of the observation group was （12.3 ± 0.9） points,which was lower than that of the control group [（15.6 ± 1.6） points] （t =11.369,P 〈 0.05）,and the quality of life score of the observation group was （56.3 ± 2.9） points,which was lower than that of the control group [（68.9 ± 5.3） points] （t =13.190,P 〈 0.05）.The fasting blood glucose in the observation group was （5.1 ± 0.9） mmol/L,which was lower than that of the control group [（7.3 ± 1.1） mmol/L] （t =9.790,P 〈 0.05）.The fasting insulin in the observation group was （6.4 ± 0.3）mU/L,which was higher than that of the control group [（4.1 ±0.1） mU/L] （t =46.000,P 〈 0.05）.Conclusion For patients with sleep apnea syndrome,nasal continuous positive airway pressure ventilation treatment can effectively improve the sleep and quality of life of patients,better regulation of blood sugar stability.