丁苯酞氯化钠注射液联合复方丹参注射液治疗急性缺血性脑卒中的效果观察

Effect of butylphthalide and sodium chloride injection combined with salvia miltiorrhiza injection in the treatment of acute ischemic stroke

目的 探讨丁苯酞氯化钠注射液联合复方丹参注射液治疗急性缺血性脑卒中的临床疗效.方法 选择华中科技大学同济黄州医院2016年1月至2017年12月收治的急性缺血性脑卒中患者104例,采用随机数字表法分为观察组52例、对照组52例.对照组给予丁苯酞氯化钠注射液治疗,观察组在对照组基础上联合复方丹参注射液治疗,两组疗程均为14 d.比较两组临床疗效.结果 观察组总有效率（90.38％）高于对照组（73.08％）（x2 =5.216,P＜0.05）.治疗后,观察组日常生活活动能力（ADL）评分为（60.49±5.46）分,高于对照组的（44.54±4.10）分（t=16.845,P＜0.05）.治疗后,观察组内皮素-1（ET-1）、C反应蛋白（CRP）、同型半胱氨酸（Hcy）分别为（37.42±5.47） ng/L、（6.51±1.89）mg/L、（7.42±1.27） μmol/L,对照组分别为（58.98±7.89） ng/L、（12.34±2.65） mg/L、（15.39±2.06） μmol/L,观察组治疗后ET-1、CRP和Hcy水平均低于对照组（t=16.194、12.916、23.749,均P＜0.05）.治疗后,观察组血浆黏度、纤维蛋白原、全血黏度高切和全血黏度低切分别为（1.20±0.23） mPa/s、（2.54±0.37） g/L、（2.54±0.37） mPa/s和（8.19±0.68） mPa/s,对照组分别为（2.09±0.32） mPa/s、（3.47±0.58） g/L、（3.46±0.59） mPa/s和（9.81±0.82） mPa/s,差异均有统计学意义（t=16.286、9.748、10.994、10.966,均P＜0.05）.结论 丁苯酞氯化钠注射液联合复方丹参注射液治疗急性缺血性脑卒中疗效显著,临床上可推广应用.

Objective To investigate the value of butylphthalide and sodium chloride injectio combined with compound salvia miltiorrhiza injection in the treatment of acute ischemic stroke.Methods From January 2016 to December 2017,104 patients with acute ischemic stroke in Tongji Huangzhou Hospital Affiliated to Huazhong University of Science and Technology were randomly divided into observation group （52 cases） and control group （52 cases） according to the digital table.The control group was given butylphthalide and sodium chloride injectio,and the observation group was combined with the compound salvia miltiorrhiza injection on the basis of the control group.The courses of the treatment in the two groups were 14 d.The effects of the two groups were compared.Results The total effective rate of the observation group（90.38%,47/52） was higher than that of the control group（73.08%,38/52） （x2 =5.216,P 〈 0.05）.After treatment,the daily living activity （ADL） score of the observation group was （60.49 ± 5.46） points,which was higher than （44.54 ± 4.10） points of the control group （t =16.845,P 〈 0.05）.After treatment,endothelin-1 （ET-1）,C reactive protein （CRP）,homocysteine （Hcy） in the observation group were （37.42 ± 5.47） ng/L,（6.51 ± 1.89）mg/L,（7.42 ± 1.27） μmol/L,respectively,which in the control group were （58.98 ± 7.89） ng/L,（12.34 ± 2.65） mg/L,（15.39 ± 2.06） μmol/L,respectively,the levels of ET-1,CRP and Hcy in the observation group were lower than those in the control group （t =16.194,12.916,23.749,all P 〈 0.05）.After treatment,the plasma viscosity,fibrinogen,whole blood viscosity at high shear and low shear whole blood viscosity of the observation group were （1.20 ± 0.23） mPa/s,（2.54 ± 0.37） g/L,（2.54 ± 0.37） mPa/s and （8.19 ± 0.68） mPa/s,respectively,which of the control group were （2.09 ± 0.32） mPa/s,（3.47 ± 0.58） g/L,（3.46 ± 0.59） mPa/s and （9.81 ± 0.82） mPa/s,respectively,the plasma viscosity,fibrinogen,whole blood viscosity at high shear and low shear whole blood viscosity of water of the observation group after treatment were lower than those of the control group（t =16.286,9.748,10.994,10.966,all P 〈 0.05）.Conclusion The effect of butylphthalide and sodium chloride injectio combined with compound salvia miltiorrhiza injection in the treatment of acute ischemic stroke is significant,which is worth studying.