2型糖尿病患者甲状腺微粒体抗体和甲状腺球蛋白抗体的变化情况及特点分析

Analysis of the changes and characteristics of TPO -Ab and TG -Ab in patients with type 2 diabetes

目的 通过研究2 型糖尿病患者体内甲状腺微粒体抗体（ TPO-Ab）和甲状腺球蛋白抗体（TG-Ab）的变化情况及特点,为糖尿病诊断和病情判断提供新的思路.方法 选取2014年1月至2017年1月太原钢铁集团（有限）公司总医院80例体检正常的健康人作为健康组;同期选取80例2型糖尿病患者作为糖尿病组,均于清晨取空腹静脉血5 mL,采用电化学发光法进行检测抗甲状腺微粒体抗体（TPO-Ab）与抗甲状腺球蛋白抗体（TG-Ab）含量.将糖尿病患者分为四组：TPO-Ab正常组、TPO-Ab升高组、TG-Ab正常组、TG-Ab升高组,比较四组的血糖、年龄、性别等情况.结果 与健康组相比,糖尿病组TPO-Ab和TG-Ab升高的比例分别高出11.25%和2.5%,差异均有统计学意义（χ2＝4.86,P＜0.05）.糖尿病患者中,TPO-Ab正常组血糖值为（6.67 ±1.53）mmol/L,升高组为（7.87 ±1.24）mmol/L,差异有统计学意义（t＝2.94,P＜0.05）;TG-Ab正常组血糖值为（6.75 ±1.34）mmol/L,升高组为（7.04 ±1.25）mmol/L,差异有统计学意义（t＝2.82, P＜0.05）. TPO-Ab和TG-Ab是否升高与年龄、性别均无明显关系,TPO-Ab正常组年龄为（62.1 ±6.3）岁,升高组为（63.0 ±4.9）岁,TG-Ab正常组年龄为（62.8 ±7.1）岁,差异无统计学意义（t＝1.37,P＞0.05）;升高组年龄为（61.6 ±2.7）岁,差异无统计学意义（ t ＝1.27,P＞0.05）.男性患者中,TPO-Ab正常占84.09%, TPO-Ab升高占15.91%;女性患者中,TPO-Ab正常占86.11%,TPO-Ab升高占13.89%,差异无统计学意义（χ2＝1.20,P＞0.05）;男性患者中,TG-Ab正常占97.73%,TG-Ab升高占2.27%;女性患者中,TG-Ab正常占97.22%,TG-Ab升高占2.78%,差异无统计学意义（χ2＝0.97,P＞0.05）.结论 2 型糖尿病患者血清TPO-Ab和TG-Ab含量升高,与血糖呈正相关,与年龄、性别无关.

Objective To study the changes and characteristics of TPO -Ab and TG-Ab in type 2 diaetic patients and provide new ideas for the diagnosis of diabetes.Methods From January 2014 to January 2017,160 samples in General Hospital of Taiyuan Iron＆Steel （Group） Co.Ltd were selected,80 healthy people and 80 patients with type 2 diabetes,fasting venous 5 mL blood was obtained in the morning ,then electrochemical luminescence method was used to test TPO-Ab and TG-Ab contents.The diabetic patients were divided into four groups ：TPO-Ab normal group,TPO-Ab elevation group,TG-Ab normal group,TG-Ab elevation group.The blood glucose,age and gender of the four groups were compared.Results Compared with the control group ,the proportions of increased TPO -Ab and TG-Ab in diabetic patients were 11.25%and 2.5%respectively,the difference was statistically significant （χ2＝4.86,P＜0.05）.In type 2 diabetic patients,the blood glucose value of the normal TPO -Ab group was （6.67 ± 1.53）mmol/L,which in the TPO -Ab elevation group was （7.87 ±1.24） mmol/L,the difference was statistically significant （t＝2.94,P＜0.05）.The blood glucose of the normal TG -Ab group was （6.75 ±1.34）mmol/L,which in the TG-Ab elevation group was （7.04 ±1.25）mmol/L,the difference was statistically significant （t＝2.82,P＜0.05）.TPO-Ab and TG-Ab elevation had no obvious relation with age ,gender.The age of the normal TPO -Ab group was （62.1 ±6.3）years,which in the TPO-Ab elevation group was （63.0 ±4.9）years,there was no statisti- cally significant difference （t＝1.37,P＞0.05）.The age of the normal TG -Ab group was （62.8 ±7.1）years,which in the TG-Ab elevation group was （61.6 ±2.7）years,the difference was not statistically significant （t＝1.27,P＞0.05）.In male patients,TPO-Ab normal accounted for 84.09%,TPO-Ab rise accounted for 15.91%.In female patients,TPO-Ab normal accounted for 86.11%,TPO-Ab rise accounted for 13.89%,there was no statistically significant difference （χ2＝1.20,P＞0.05）.In male patients,TG-Ab normal accounted for 97.73%,TG-Ab rise accounted for 2.27%, in female patients, TG -Ab normal accounted for 97.22%, TG -Ab rise accounted for 2.78%,there was no statistically significant difference （χ2＝0.97,P＞0.05）.Conclusion TPO-Ab and TG-Ab in type 2 diabetes patients are higher than healthy people.The increase of TPO -Ab and TG -Ab is positively correlated with blood glucose level.The increase of TPO-Ab and TG-Ab is not correlated with age and gender.