盐酸利托君、硝苯地平、硫酸镁对先兆早产孕妇的宫缩抑制作用及对心率、血压、妊娠结局的影响

Inhibitory effect of Ritodrine Hydrochloride, Nifedipine and Magnesium Sulfate on uterine contraction in pregnant woman with threatened premature labor and its effects on heart rate, blood pressure and pregnancy outcome

目的探析先兆早产孕妇采用硝苯地平、盐酸利托君与硫酸镁治疗的临床可行性。方法 90例先兆早产孕妇,随机分为A组、B组和C组,各30例。A组给予盐酸利托君治疗,B组给予硝苯地平治疗,C组给予硫酸镁治疗。对比三组治疗效果。结果 A组保胎成功率为96.7%,B组保胎成功率为93.3%,C组保胎成功率为76.7%;A组保胎成功率高于C组,差异具有统计学意义(P<0.05);A组与B组保胎成功率比较,差异无统计学意义(P>0.05)。三组孕妇治疗前后血压比较,差异无统计学意义(P>0.05);A组治疗后心率、副反应发生率明显高于B组、C组,差异具有统计学意义(P<0.05);B组与C组治疗后心率、副反应发生率比较,差异无统计学意义(P>0.05)。结论先兆早产孕妇应用硫酸镁、盐酸利托君以及硝苯地平治疗均可对宫缩进行抑制,但每种药物有各自的特性,建议实际应用时选用硝苯地平,安全性与有效性更高。

Objective To investigate the clinical feasibility of Nifedipine, Ritodrine Hydrochloric and Magnesium Sulfate in pregnant woman with threatened premature labor. Methods A total of 90 pregnant woman with threatened premature labor were randomly divided into group A, group B and group C, 30 cases in each group. Group A was treated with Ritodrine Hydrochloride, group B was treated with Nifedipine, and group C was treated with Magnesium Sulfate. The treatment effects among the three groups were compared. Results The tocolysis success rate of group A, group B and group C were 96.7%, 93.3% and 76.7% respectively, the tocolysis success rate of group A was significantly higher than group C, the difference was statistically significant（P0.05）. But there was no statistically significant difference in the tocolysis success rate between the group A and group B（P0.05）. There was no significant difference in the blood pressure among the three groups before and after treatment（P0.05）, and the heart rate and incidence rate of side effects in the group A was significantly higher than those in the group B and the group C, the differences were statistically significant（P0.05）. There was no significant difference in the the heart rate and incidence rate of side effects between the group B and group C（P0.05）. Conclusion The application of Magnesium Sulfate, Ritodrine Hydrochloride and Nifedipine can inhibit uterine contraction, but each drug has its own characteristics. It is suggested that Nifedipine should be used in practical application, with higher safety and effectiveness.