525例溃疡性结肠炎患者临床特征分析

Clinical Feature Analysis of 525 Cases of Patients with Ulcerative Colitis

目的:回顾性分析江苏省中医院溃疡性结肠炎患者的临床特征。方法:收集江苏省中医院溃疡性结肠炎住院病历,对患者的性别、年龄、病程、临床类型、病情分期、严重程度、病变部位、主要症状等临床特征进行回顾性分析。结果:研究纳入男性290例,女性235例,男女比例为1.2:1;发病高峰年龄为20~60岁;饮食因素是最常见诱因,其次为劳累、环境、药物及情志因素。病情分期显示,缓解期28例(5.33%),活动期497例(94.67%)。活动期患者中,初发型78例(15.69%),慢性复发型419例(84.31%);直肠型92例(18.51%),左半结肠型156例(31.39%),广泛结肠型249例(50.10%);严重程度统计显示,轻度275例(55.33%),中度149例(29.98%),重度73例(14.69%)。主要症状为脓血便、腹泻、腹痛。脓血便者375例(71.43%),治疗后消失率为89.07%;腹泻者335例(63.81%),治疗后消失率为71.64%;腹痛者319例(60.76%),治疗后消失率为85.89%。共有3例(0.57%)患者出现并发症。药物治疗以中西医结合为主(86.29%),中医治疗包括中药口服453例(87.45%),中药灌肠401例(77.41%),中药泡脚10例(1.93%);西医治疗包括氨基水杨酸制剂口服392例(75.68%),氨基水杨酸制剂塞肛100例(19.31%),激素88例(16.99%),免疫抑制剂18例(3.47%)和微生态制剂441例(85.14%)。结论:我院收治的溃疡性结肠炎住院患者以慢性复发型、活动期、轻中度、广泛结肠型为主,治疗以中西医结合为主,主要症状脓血便、腹泻、腹痛改善明显,99.61%患者好转出院。

Objective： To conduct retrospective analysis of clinical features of patients with ulcerative colitis in JiangsuProvince Hospital of Traditional Chinese Medicine（TCM）. Methods： Ulcerative colitis medical records in jiangsuprovince hospital of TCM were selected and used to retrospectively analyze the feature such as gender, age, course of thedisease, clinical type, stage, severity, and pathological parts. Results： The study include 290 cases of male and 235 casesof female with the ratio of 1.2：1. Peak incidence was between 20 to 60 years old. Dietary factor was the most commoncause, followed by fatigue, environment, medicine and emotional factors. There were 28（5.33%） patients at remissionstage, and 497（94.67%） patients at active stage. In patients at active stage, there were 78（15.69%） patients newlydiagnosed, and 419（84.31%） patients with chronic recurrent type. There 92（18.51%） rectum type patients, 156（31.39%）left half colon type patients and 249（50.10%） extensive colon type patients. There were 275（55.33%） mild patients, 149（29.98%） moderate patients and 73（14.69%） severe patients. The main symptoms were bloody purulent stool, diarrheaand abdominal pain. There were 375（71.43%） patients with bloody purulent stool, and symptom disappearance rate was89.07% after treatment. There were 335（63.81%） patients with diarrhea, and symptom disappearance rate was 71.64%after treatment. There were 319（60.76%） patients with abdominal pain, and symptom disappearance rate was 85.89%after treatment. There were 3 cases of complications. Drug therapy was mainly based on integrated Chinese and westernmedicine（86.29%）. For Chinese medicine treatment, there were 453 patients（87.45%） with oral Chinese medicine, 401 patients（77.41%） with Chinese medicine enema, and 10 patients（1.93%） with foot bath. For western medicine treatment,there were 392 patients（75.68%） treated with oral amino salicylate drugs, 100 patients（19.31%） with anal used aminosalicylate drugs, 88 patients（16.99%） with glucocorticoid, 18 patients（3.47%） with immunosuppressive agent and 441 patients（85.14%） with microecological preparation. Conclusion： The types of ulcerative colitis patients in our hospitalwere mainly chronic recurrent type at active stage with mild to moderate and extensive colon type. The treatment wasmainly based on integrated Chinese and western medicine, with significant improvement in symptoms of bloody purulentstool, diarrhea and abdominal pain. 99.61% patients were discharged with a better condition