循环肿瘤细胞检测对评估胃癌患者预后的价值

Clinical value of circulating tumor cell detection in evaluating the prognosis of patients with gastric cancer

目的探讨循环肿瘤细胞（circulating tumor cell，CTC）检测在胃癌术后患者预后评估中的作用。方法收集2014-2015年宁波市第一医院在系统治疗前的Ⅰ-Ⅳ期65例胃癌患者和20例正常人的外周血，利用CellSearch循环肿瘤细胞检测系统检测CTC，绘制其无进展生存期和总生存期曲线并与胃癌患者的临床病理因素进行统计分析。结果65例胃癌患者中35例检出CTC细胞，占53％。对照组20例中1例CTC阳性，占5％，两组相比差异有统计学意义，P〈0．05。CTC检出结果与胃癌患者的性别、年龄、淋巴结转移、远处器官转移、脉管侵犯、血清肿瘤指标均无关（均P〉0．05）。CTC阳性胃癌患者的总生存期（P〈0．05）和无进展生存期（P〈0．05）比CTC阴性胃癌患者短。检测到的CTC〉3个组胃癌患者较CTC≤3个组胃癌患者的预后更差。结论CTC检测阳性胃癌患者的预后不良。

Objective To evaluate circulating tumor cells （CTC） in prognosis prediction of gastric cancer. Method Peripheral blood samples were obtained from 65 patients with gastric cancer and 20 normal volunteers. CTC were detected by using CellSearch CTC Detecting System. Postoperative progress-free survival （PFIS） and overall survival （OS） were evaluated against CTC status and elinicopathological factors. Result CTC were positive in 35 out of 65 （53%） patients compared to 1 out of 20 （5%） healthy controls, P 〈0. 05. CTC were not statistically eorelated with patients＇ age,sex and lymph node status or distal metastasis, vascular invasion and tumor markers （ all P 〉 0. 05 ）. CTC positive patients had poorer OS （ P 〈 O. 05 ） and PFS （ P 〈 0. 05 ） compared with those with negative CTC. Conclusion Positive CTC in gastric cancer natients nredict noor nro^nosis after radical gastrectomv.