通心络胶囊对冠心病患者血液流变学影响的Meta分析

Meta Analysis of The Effects of The Tongxinluo Capsule for Hemorheology Among Patients with Coronary Heart Disease

目的:评价通心络胶囊对冠心病患者血液流变学的影响。方法:检索"Pubmed""CNKI""VIP"及"万方"等数据库从建库至2017年6月发表的相关文献,对符合要求的随机对照试验进行Meta分析。结果:纳入文献10篇,共纳入981例样本量,其中使用通心络治疗的有519例,常规疗法462例。与传统西医疗法相比较,通心络胶囊治疗组总有效率明显优于常规治疗组,高切变速率下全血黏度下降更多,低切全血黏度、血浆黏度降低更显著,纤维蛋白原减少更明显。结论:通心络胶囊改善患者血液流变学的疗效优于常规西药。

Objective： To evaluate effects of Tongxinluo capsule for hemorheology among patients with coronary heart disease. Methods： Searches were performed for randomized controlled trials among electronic databases（Pub Med,CNKI,VIP,Wanfang） before to Jun 2017. Meta-analysis was conducted on randomized controlled trial to evaluate the clinical effects. Results： 10 clinical controlled studies were included. The total number of patients was 981 patients,including 519 patients with Tongxinluo capsule treatment and 462 with regular treatment. Compared with regular group,the total effective rate of Tongxinluo capsule group was obviously higher high shear rate whole blood viscosity,low shear rate whole blood viscosity（LSWBV）,blood Plasma viscosity（BPV） and fibrinogen. Conclusion： Compared with regular medicine,Tongxinluo capsule have greater clinical effect to improve hemorheology among CHD patients.