腺苷系统对睡眠调节作用的研究进展

Progress in regulation of adenosine system on sleep

已有的证据表明腺苷系统通过抑制促觉醒系统和兴奋促睡眠系统的协同作用而调节睡眠。药理学及遗传学的手段改变腺苷水平、腺苷受体活性均能影响睡眠时间及结构。但是，有关腺苷系统在睡眠障碍患者中是否有改变的研究尚少。为了唤起对腺苷系统的临床睡眠研究的关注，我们就腺苷的一般情况（产生、代谢、外周分布及昼夜节律性）、对睡眠的调节及其机制、腺苷受体对睡眠调节作用的差异的研究进展进行了综述。文末展望了腺苷系统作为临床治疗失眠新靶点的潜在意义及慢性失眠状态下对腺苷系统的进一步研究方向。

The growing evidence suggests that adenosine system can regulate sleep-wake through the cooperation between inhibition of promoting wake system and excitement of promoting sleep system. Changes in adenosine level and adenosine receptor activity by pharmacological and genetic methods can affect sleep time and structure. However, the studies on whether the changes exist in the adenosine system in the patients with chronic insomnia disorder remain rare. In order to arouse the close attention to the clinical sleep study of adenosine system, in this paper, we present an overview of the current research progress regarding adenosine in general knowledge （adenosine＇s production, metabolism, peripheral distribution, circadian rhythm） , the regulation of sleep and its mechanism, and the differences in regulation of sleep for various adenosine receptors. In the end, we propose some research directions of adenosine system under chronic insomnia after pointing out the existing issues currently.