小儿柴桂退热颗粒辅助治疗对急性上呼吸道感染的疗效及对炎性因子水平的影响

Analysis of Inflammatory Factors and Main Symptoms in Acute Upper Respiratory Tract Infection Treated by Chaigui Tuire Granule

目的：柴桂退热颗粒辅助治疗对急性上呼吸道感染的疗效及对炎性因子水平的影响。方法：回顾性选取2012年1月-2016年11月医院收治的急性上呼吸道感染患儿500例，根据用药不同分为对照组和观察组。对照组患儿采用常规抗生素、抗病毒制剂等常规对症治疗，观察组患儿在常规对症治疗基础上联合小儿柴桂退热颗粒治疗。观察两组患儿治疗后主要症状改善情况及对免疫功能指标、超敏C反应蛋白（hs-CRP）、半胱氨酰白三烯（CyslTs）、血清腺普脱氨酶（ADA）及细胞间黏附分子-1（ICAM-1）水平的影响。结果：两组患儿治疗后发热、咳嗽、鼻塞、咽干及纳少积分均较治疗前改善，观察组患儿治疗后主要症状积分优于对照组（P〈0．05）。观察组患儿主要症状消失时间均短于对照组（P〈0．05）。两组患儿治疗后hs-CRP、CyslTs、ADA及ICAM-1水平均较治疗前下降，观察组患儿治疗后hs-CRP、CyslTs、ADA及ICAM-1水平均低于对照组（P〈0．05）。两组患儿治疗后IgA和IgM水平均较治疗前下降，IgG水平较治疗前上升，观察组患儿治疗后免疫功能指标水平均优于对照组（P〈0．05）。结论：小儿柴桂退热颗粒辅助治疗急性上呼吸道感染可有效改善患儿I临床症状，降低患儿hs—CRP、CyslTs、ADA及ICAM-1水平，调节患儿免疫功能。

Objective ： To analyze the inflammatory factors and the main symptoms of acute upper respiratory tract infection treated by Chaigui Tuire Granules. Methods：A total of 500 acute upper respiratory tract patients from January 2012 to November 2016 in our hospital, according to the medication were divided into control group and observation group. The control group was treated with conventional antibiotics, antiviral agents and other conventional symptomatic treatment. The observation group on the basis of conventional symptomatic treatment combined with Chaigui Tuire Granules treat- ment. We observed two groups＇ main symptoms of immune function, high sensitive C reactive protein （hs -CRP） , eys- teinyl leukotrienes （CyslTs） , serum P deaminase （ADA） and intercellular adhesion molecule - 1 （ICAM - 1 ） levels. Results：After treatment,the two groups＇ fever, cough, stuffy nose, throat and eatless integral were improved and the main symptoms of observation group after treatment was better than those of the control group（P 〈 0. 05 ）. The main symptoms disappeared time was shorter than that of the control group （P 〈 0. 05）. The two groups＇ hs - CRP, CyslTs, ADA and ICAM - 1 levels after treatment were lower than those before treatment. The observation group＇ s hs - CRP, CyslTs, ADA and ICAM - 1 levels after treatment were lower than those of the control group（ P 〈 0. 05 ）. The two groups＇ IgA and IgM levels after treatment were lower than that before treatment. The level of IgG was higher than that before treatment, and the level of immune function in the observation group after treatment was better than that in the control group （P 〈 0. 05 ）. Conclusion ： Chaigui Tuire Granule in the adjuvant treatment of acute upper respiratory tract infection can effec- tively improve the clinical symptoms, reduce the levels of hs - CRP, CyslTs, ADA and ICAM - 1 and regulate the immune function.