布-加综合征患者血浆NO、CO及内皮素测定

Plasma carbon monoxide levels and their influence factors in patients with Budd-Chiari syndrome

目的 :探讨布 加综合征患者血浆一氧化碳 (CO)的水平和影响因素 ,以及CO在布 加综合征发病中的作用和意义。方法 :测定了 30例布 加综合征患者分流减压术前后外周血浆中CO、一氧化氮 (NO)及内皮素 1 (ET 1 )的水平 ,并以 30例正常人为对照。结果 :布 加综合征患者手术前血浆CO、NO及ET 1的水平均显著高于正常对照组 (CO (0 .89± 0 .1 1 )mg/L ,(0 .42± 0 .1 3)mg/L ;NO(87.31± 1 0 .41 ) μmol/L ,(55 .2 3± 1 0 .2 3) μmol/L ;ET 1(80 .0 2± 1 0 .89)ng/L ,(48.75± 1 1 .50 )ng/L ,P均 <0 .0 5) ,分流术后 3者的水平有明显下降 (P均 <0 .0 5)。 结论 :CO可能参与了布 加综合征的病理生理过程 。

Aims: To investigate plasma carbon monoxide (CO) levels and their influence factors in patients with Budd Chiari syndrome(B CS). Methods:The preoperative and postoperative plasma CO,nitric oxide(NO),and endothelin 1(ET 1) levels were mensured in 30 patients with B CS who underwent shunt operations. Results: Plasma levels of both vasodilator (CO,NO) and vasoconstrictor(ET 1) in the B CS group were significantly higher than those in the normal control group (0.89±0.11) mg/L vs (0.42±0.13) mg/L for CO;(87.31±10.41) nmol/L vs (55.23±10.23) nmol/L for NO;(80.02±10.89) ng/L vs (48.75±11.50) ng/L for ET 1;all P <0.05). Conclusions: CO might involve in the pathophysiology of B CS.The elevated portal venous pressure might be one of the stimulated factors for the high production of CO.