胰腺癌组织中FHL1、Prx1异常表达与临床预后的关系探究

Relationship between abnormal expression of FHL1 and Prx1 and clinical prognosis in pancreatic cancer

目的探讨胰腺癌组织中四个半LIM结构域蛋白1(FHL1)、过氧化物还原酶1(Prx1)的异常表达与临床预后的关系。方法选取内江市第一人民医院于2011年5月至2012年5月期间收治的68例胰腺癌患者,观察并记录患者的性别、年龄、肿瘤大小、肿瘤部位、肿瘤FHL1/癌旁FHL1及Prx1表达情况、存活时间,并探究FHL1、Prx1异常表达与临床预后的相关性。结果神经侵犯、淋巴结转移、肿瘤分化程度、TNM分期、Prx1表达等与胰腺癌患者的预后呈正相关(P<0.05);肿瘤FHL1/癌旁FHL1与胰腺癌患者的预后呈负相关(P<0.05),肿瘤FHL1/癌旁FHL1的降低提示胰腺癌患者预后不良;Prx1低表达组患者的存活时间明显高于Prx1高表达组,FHL1高表达组患者的存活时间明显高于FHL1低表达组,差异均具有统计学意义(P均<0.05)。结论胰腺癌组织中FHL1、Prx1异常表达与临床预后显著相关,FHL1的低表达及Prx1的高表达均提示胰腺癌患者预后不良。

Objective This paper attempts to investigate the relationship between abnormal expression of four and half LIM domain protein 1 （FHL1）,peroxide reductase 1 （Prx1） and clinical prognosis in pancreatic cancer.Methods Sixty-eight patients with pancreatic cancer admitted from May 2011 to May 2012 were selected,to observe and record the sex,age,tumor size, tumor location, cancer FHL1/para-cancer FHL1 and Prx1 expression,survival time,and to explore the correlation between the abnormal expression of FHL1 and Prx1 and the clinical prognosis.Results Nerve invasion, lymph node metastasis, tumor differentiation, TNM stage, Prx1 expression were positively correlated with prognosis of pancreatic cancer （P〈0.05）.Cancer FHL1/para-cancer FHL1 and the prognosis of patients with pancreatic cancer were negatively correlated （ P〈0.05）.The decrease of cancer FHL1/para-cancer FHL1 suggested that the prognosis of pancreatic cancer patients was poor. The survival time of the low expression group was significantly higher than that of the high Prx1 expression group of Prx1 （ P〈0.05 ）. The survival time of the high expression group was significantly higher than that of the low expression group of FHL1 （P〈0.05）.Conclusions The abnormal expression of FHL1 and Prx1 in pancreatic cancer is significantly correlated with clinical prognosis. The low expression of FHL1 and the high expression of Prx1 suggest that the prognosis of pancreatic cancer is poor.