尿激酶与经皮冠状动脉介入术治疗老年急性心肌梗死临床研究

Clinical Study of Urokinase and Percutaneous Coronary Intervention in Elderly Patients with Acute Myocardial Infarction

目的:探究老年急性心肌梗死经尿激酶与经皮冠状动脉介入术治疗的临床效果。方法:将2015年8月~2017年4月某院经诊断确诊为老年急性心肌梗死的患者80例纳为本次研究的对象,依照随机数字表法均分为PCI组和溶栓组,前者采取经皮冠状动脉介入治疗,后者采取尿激酶溶栓治疗,治疗前后统计对比两组LVEF、LVEDD、出血以及再通情况。结果:(1)治疗结束后,PCI组在LVEF、LVEDD、再通率和出血率方面对比溶栓组均具有显著优势,对比差异具有统计学意义(P<0.05);(2)治疗后PCI组心律失常改善的效果优于溶栓组,有统计学意义(P<0.05)。结论:溶栓和PCI治疗老年急性心肌梗死的临床疗效均较好,但PCI能够提高闭塞冠状动脉再通率,实现心肌再灌注,改善心律失常,并且出血率更低,因此建议推广至临床应用。

Objective：To explore the clinical effect of urokinase and percutaneous coronary intervention in elderly patients with acute myocardial infarction.Methods：80 patients with acute myocardial infarction diagnosed in a hospital from August 2015 to April 2017 were divided into PCI group and thrombolytic group according to the random digital table method.The former was treated with percutaneous coronary intervention,and the latter was treated with urokinase thrombolysis.LVEF,LVEDD,bleeding and recanalization were compared between the two groups before and after treatment.Results：（1）After treatment,group PCI had significant advantages in LVEF,LVEDD,repassage rate and bleeding rate compared with the thrombolytic group,and the difference was statistically significant（P〈0.05）.（2）After treatment,the improvement of arrhy thmiain PCI group was better than that of thrombolytic group（P〈0.05）,with statistical significance.Conclusion：The therapeutic effect of thrombolytic and PCI in the treatment of acute myocardial infarction is good,but PCI can improve the recanalization rate of coronary artery occlusion,realizing myocardial reperfusion,improving arrhythmia,and having lower bleeding rate,so it is suggested to be popularized to clinical application.