穴位注射联合沙美特罗替卡松粉吸入剂治疗慢性阻塞性肺疾病稳定期的临床疗效观察

Clinical Observation of Acupoint Injection Combined with Salmeterol and Fluticasone Powder Inhalation in the Treatment of Chronic Obstructive Pulmonary Disease

目的观察穴位注射黄芪注射液联合沙美特罗替卡松粉吸入剂(舒利迭)治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法选取2016年8月~2018年2月上海市宝山区中西医结合医院呼吸内科门诊慢性阻塞性肺病临床缓解期的患者66例,随机分为试验组和对照组,各33例。对照组予以舒利迭治疗,试验组予以穴位注射黄芪注射液联合舒利迭治疗,疗程均2个月。观察两组治疗前后中医证候积分主证分、CAT评分、血清IL-8变化。结果治疗后,两组中医证候主证分均改变,试验组与治疗前比较差异有统计学意义(P<0.05),对照组与治疗前比较差异无统计学意义(P>0.05),且试验组与对照组主证分改变比较,差异有统计学意义(P<0.05);治疗后,试验组CAT评分下降优于对照组,差异有统计学意义(P<0.05);治疗后,试验组IL-8水平下降优于对照组,差异有统计学意义(P<0.05)。结论穴位注射能改善慢性阻塞性肺疾病患者的中医证候主证分,降低患者的炎症介质,提高患者的生活质量。

Objective To observe the clinical efficacy of acupoint injection of Astragalus injection combined with salmeterol and fluticasone powder inhalation（Sulidide）in the treatment of chronic obstructive pulmonary disease（COPD）. Methods A total of 66 patients with clinical remission of chronic obstructive pulmonary disease in the Department of Respiratory Medicine,Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine from August 2016 to February 2018 were randomly divided into the experimental group and the control group,33 cases each.The control group was treated with sulidide,and the experimental group was treated with acupoint injection of astragalus injection combined with sullidide for 2 months.The scores of the main syndrome,CAT score and serum IL-8 of TCM syndromes before and after treatment were observed. Results After treatment,the scores of TCM syndromes in the two groups were changed,there was significant difference between the experimental group and the pre-treatment（P〈0.05）.There was no significant difference between the control group and the pre-treatment（ P〉0.05）,the test group and the control group were compared with the main syndrome scores,the difference was statistically significant（ P〈0.05）.After treatment,the CAT score of the experimental group was lower than that of the control group,and the difference was statistically significant（ P〈0.05）.After treatment,the IL-8 level of the test group was lower than that of the control group,the difference was statistically significant（ P〈0.05）.Conclusion Acupoint injection can improve the syndrome of TCM syndromes in patients with chronic obstructive pulmonary disease, reduce the inflammatory mediators and improve the quality of life of patients.