腹腔镜下垂体后叶素注射对卵巢储备功能的影响研究

Effect of laparoscopichypophysin injection on the ovarian reserve function of patients

目的:探讨腹腔镜下垂体后叶素注射对卵巢储备功能的影响。方法:选取张家港市第一人民医院2013年9月至2016年9月期间收治的卵巢内异囊肿患者104例,按照随机表法将其分为观察组和对照组,每组52例。两组患者均实施腹腔镜手术治疗。对照组不给予注射垂体后叶素;观察组给予注射垂体后叶素。比较两组术后腹腔引流量、术后肛门排气时间、术中出血量,术前和术后6个月卵巢体积和基础状态卵泡数及血清LH和FSH水平变化。结果:两组患者术后腹腔引流量比较,差异无统计学意义(P>0.05);观察组患者术后肛门排气时间快于对照组,而术中出血量少于对照组,差异均有统计学意义(均P<0.05);两组患者术后6个月卵巢体积和基础状态卵泡数均有所降低,差异具有统计学意义(P<0.05);观察组患者术后6个月卵巢体积和基础状态卵泡数高于对照组,差异具有统计学意义(P<0.05);观察组患者术前和术后6个月血清LH和FSH水平比较,差异无统计学意义(P>0.05);对照组患者术后6个月血清LH和FSH水平增加,差异具有统计学意义(P<0.05);观察组患者术后6个月血清LH和FSH水平低于对照组,差异具有统计学意义(P<0.05)。结论:腹腔镜下垂体后叶素注射治疗卵巢内异囊肿可以有效保护卵巢储备功能,具有重要研究价值。

Objective： To study the effect of laparoscopic hypophysin injection on the ovarian reserve function of patients. Methods： 104 patients with ovarian endometriosis in Zhangjiagang First People＇s Hospital from September 2013 to September 2016 were randomly divided into observation group（ 52 cases） and control group（ 52 cases）. Patients in both groups were treated with laparoscopic surgery and the observation group was injected with hypophysin while the control group was not. The postoperative abdominal drainage volume,postoperative anal exhaust time and intraoperative blood loss,changes in the volume of ovary,the number of underlying follicles and the serum levels of LH and FSH between 6 months before and after surgery were compared between the two groups.Results： There was no statistically significant difference in postoperative abdominal drainage volume between the two groups（ P 〉 0. 05）. The postoperative anal exhaust time of the observation group was shorter than the control group,and the intraoperative blood loss was less than the control group,both with statistically significant difference（ all P 〈 0. 05）. The ovarian volume and basal follicle number were decreased in both groups after surgery,with statistically significant difference（ P 〈 0. 05）. The ovarian volume and basal follicle number in the observation group was larger than the control group,with statistically significant difference（ P 〈 0. 05）. There was no significant difference in serum LH and FSH levels between 6 months before and after surgery in the observation group（ P 〈 0. 05）,while the serum LH and FSH levels increased at 6 months after surgery in the control group,with statistically significant difference（ P 〈 0. 05）. The serum LH and FSH levels in the observation group was lower than the control group at6 months after surgery,with statistically significant difference（ P 〈 0. 05）. Conclusions： laparoscopic hypophysin injection in the treatment of ovarian endometriosis cyst can effectively protect the ovarian reserve function of patients,which worth further study.