肺腺癌胸苷酸合成酶表达与放射敏感性的关系

The relationship between thymidylate synthase expression and radiosensitivity of lung adenocarcinoma

目的:探讨肺腺癌患者胸苷酸合成酶(TS)不同表达水平与放射敏感性的关系。方法:对经病理确诊的94例局部晚期肺腺癌患者,根据TS不同表达水平,将患者分为高表达组(40例)和低表达组(54例)。对患者的肺部原发病灶行体部伽玛刀立体定向适形放射治疗,放疗结束后1个月复查胸部CT评价近期疗效。结果:全部患者均按计划完成治疗,两组近期疗效:高表达组:CR 3例,PR 27例,SD 7例,PD 3例,近期总有效率为75.0%[(CR+PR)/总病例数×100%];低表达组:CR 8例,PR 41例,SD 3例,PD 2例,近期总有效率为90.7%。两组近期疗效比较差异有统计学意义(P<0.05)。结论:肺腺癌TS低表达组的放疗后近期疗效好,提示TS表达水平可能作为肺腺癌放射敏感性的标志物之一。

Objective： To investigate the relationship between the levels of thymidylate synthetase（ TS） and radiosensitivity in patients with lung adenocarcinoma.Methods： Atotal of 94 patients with locally advanced lung adenocarcinoma confirmed by pathology were divided into high expression group（ 40 cases） and low expression group（ 54 cases） according to the different expression level of TS.The patients＇ primary lung lesions were treated with body gamma knife stereotactic radiotherapy,and 1 months after the end of the radiotherapy,the immediate effect of the chest CT was reviewed.Results： All the patients completed the treatment according to the plan.The short-term efficacy of the two groups were as follows： In high expression group with CR 3 cases,PR 27 cases,SD 7 cases and PD 3 cases,the total effective rate was 75.0% [（ CR ＋ PR）/total cases × 100%].In low expression group with CR 8 cases,PR 41 cases,SD 3 cases,and PD 2 cases,the recent total effective rate was 90.7%.There was a significant difference in the recent curative effect between the two groups（ P 0.05）.Conclusion： The short term radiotherapy effect of TS low expression group of lung adenocarcinoma is good,suggesting that the expression level of TS may be one of the markers of radiosensitivity of lung adenocarcinoma.