男性雄激素性脱发患者相关实验室指标的变化

Changes of clinical laboratory determination indicators in male androgenic alopecia patients

目的探讨男性雄激素性脱发(MAA)患者实验室指标的变化,为MAA的诊治提供新的线索。方法检测430例MAA患者(MAA组)及617名体检健康者(正常对照组)甲状腺相关指标、肿瘤标志物、生化指标、免疫指标和血黏度共52项实验室指标,对2个组的检测结果进行比较。结果 MAA组胰岛素(INS)、游离前列腺特异性抗原(f-PSA)、f-PSA/总前列腺特异性抗原(t-PSA)比值、载脂蛋白E(apo E)及全血黏度:中切(50/s)水平分别为(10.49±0.86)μU/mL、(0.45±0.03)μg/L、0.31±0.02、(1.12±0.01)g/L、7.40±0.04,均明显高于正常对照组(P<0.05、P<0.01);其他各项指标2个组之间差异均无统计学意义(P>0.05)。结论 MAA患者有部分实验室指标存在一定的变化,可能与代谢综合征(MS)等具有一定的关联。

Objective To investigate the changes of clinical laboratory determination indicators in male androgenic alopecia（MAA） patients,and to provide new clues for the diagnosis and treatment of MAA.Methods A total of 52 clinical laboratory determination indicators of thyroid-related markers,tumor markers,biochemical indicators,immune indicators and blood viscosity were determined in 430 MAA patients and 617 healthy subjects（healthy control group）. The results of the 2 groups were analyzed comparatively.Results The level of insulin（INS）was（10.49±0.86）μU/ mL,the level of free prostate-specific antigen（f-PSA） was（0.45±0.03）μg/L,the ratio of f-PSA/total prostate-specific antigen（t-PSA） was 0.31±0.02,the level of apolipoprotein E（apo E） was（1.12±0.01）g/L,and the whole blood viscosity：middle cut（50/s） was 7.40±0.04,which were higher than those in healthy control group（P〈0.05,P〈0.01）. There was no statistical significance for the other indicators between the 2 groups（P〉0.05）.Conclusions Some clinical laboratory determination indicators have changes in MAA patients,which may have correlations with metabolic syndrome（MS）.