萎缩性阴道炎患者雌激素治疗后阴道局部环境的变化

Changes of Vaginal Environment after Estrogen Therapy in Patients with Atrophic Vaginitis

目的探究雌激素对萎缩性阴道炎患者的治疗效果及其对阴道局部环境的影响。方法方便该院2015年6月—2017年6月收治的86例萎缩性阴道炎患者,按数字表法分为2组,对照组常规药物治疗,观察组在对照组前提下实施雌激素治疗,对比两组疗效。结果观察组治疗总有效率97.67%,明显比对照组81.40%高(χ~2=6.081,P=0.014);对照组与观察组治疗90 d与半年后的阴道健康健康评分分别为(8.13±1.74)分vs(11.16±2.23)分,(8.26±1.84)分vs(10.36±2.35)分明显高于治疗前,且观察组治疗后阴道健康评分高于对照组(t=7.025,P=0.000,t=4.613,P=0.000);治疗后两组患者阴道pH值与E2水平(5.63±0.26)vs(4.26±0.35),(50.26±10.14)pmol/L vs(57.26±10.02)pmol/L均优于治疗前,且观察组患者的阴道pH值与E2水平优于对照组(t=20.605,P=0.000,t=3.220,P=0.000);治疗期间无阴道出血等相关不良反应。结论雌激素对萎缩性阴道炎患者的治疗效果显著,可使阴道局部环境显著改善。

Objective This paper tries to explore the therapeutic effect of estrogen on patients with atrophic vaginitis and its effect on the local environment of vagina. Methods 86 patients with atrophic vaginitis treated in the hospital from June2015 to June 2017 were convenient selected and divided into 2 groups according to the digital table method. The control group received routine drug treatment, while the observation group received estrogen treatment under the premise of the control group, and the efficacy of the two groups was compared. Results The observation group had a total effective rate of97.67%, which was significantly higher than that of the control group（81.40%）（χ^2=6.081, P=0.014）. The vaginal health scores of the control group and the observation group after 90 days and six months of treatment were（8.13±1.74）points. The scores（11.16±2.23）,（8.26±1.84）pomts vs（10.36±2.35）pomts were significantly higher than before treatment, and the vaginal health score of the observation group after treatment was higher than that of the control group（t=7.025, P=0.000, t=4.613）.（P=0.000）; after treatment, vaginal p H values and E2 levels（5.63±0.26） vs（4.26±0.35）,（50.26±10.14）pmol/L vs（57.26±10.02） pmol/L were superior to the treatment. Before and in the observation group, the vaginal p H value and E2 level were better than those in the control group（t=20.605, P=0.000, t=3.220, P=0.000）; there was no vaginal bleeding or other adverse reactions during the treatment period. Conclusion The therapeutic effect of estrogen on patients with atrophic vaginitis is significant, and the vaginal environment can be significantly improved.