阿莫西林克拉维酸钾联合阿奇霉素治疗小儿肺炎的临床效果

Clinical Efficacy of Amoxicillin and Clavulanate Combined with Azithromycin in Children with Pneumonia

目的探讨阿莫西林克拉维酸钾联合阿奇霉素治疗小儿肺炎的临床效果。方法随机选取包头医学院第二附属医院儿科2017年1—12月期间收治的150例小儿肺炎患儿作为研究对象。根据治疗方法的不同,采取随机数字表法,将150例小儿肺炎患儿分为实验组、对照组2组,各75例。对照组单一应用阿奇霉素,实验组联合应用阿莫西林克拉维酸钾、阿奇霉素。比较2组的临床疗效、症状消失时间及不良反应发生情况。结果实验组的治疗总有效率94.67%明显高于对照组的治疗总有效率81.33%(χ~2=8.541,P=0.021);实验组的咳嗽症状消失时间(5.24±1.37)d]、肺啰音症状消失时间(4.05±1.22)d、发热症状消失时间(2.12±0.58)d以及住院时间(6.25±2.13)d明显短于对照组的咳嗽症状消失时间[(9.15±1.81)d、肺啰音症状消失时间(7.24±2.13)d、发热症状消失时间(4.25±1.32)d以及住院时间(12.14±2.67)d(t=6.514、5.678、5.247、9.472,P=0.037、0.042、0.045、0.013);实验组的不良反应发生率5.33%明显低于对照组的不良反应发生率17.33%,差异均有统计学意义(χ~2=6.584,P=0.036)。结论阿莫西林克拉维酸钾联合阿奇霉素治疗小儿肺炎,疗效确切,安全性好,值得推广。

Objective This paper tries to investigate the clinical effect of amoxicillin and clavulanate combined with azithromycin in children with pneumonia. Methods 150 children with pneumonia admitted to the Department of Pediatrics of the Second Affiliated Hospital of Baotou Medical College from January to December 2017 were randomly selected as the study subjects. According to the different treatment methods, a random number table method was adopted. 150 cases of children with pneumonia were divided into experimental group and control group, each with 75 cases. Azithromycin was used alone in the control group, and amoxicillin and clavulanate and azithromycin were used in the experimental group. The clinical efficacy, the disappearance of symptoms, and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the experimental group was 94.67%, which was significantly higher than that of the control group（81.33%）（χ^2=8.541, P=0.021）; the disappearance time of the cough symptoms in the experimental group was [（5.24±1.37）days], lungs disappearance of voice symptoms [（4.05±1.22）days], fever symptoms disappeared[（2.12 ±0.58）days], and length of hospital stay [（6.25 ±2.13）days] were significantly shorter than the control group＇s cough symptom disappearance time [（9.15 ±1.81）days], pulmonary rales symptom disappearing time [（7.24±2.13）days], fever symptom disappearing time [（4.25±1.32）days] and hospitalization time[（12.14±2.67）days]（t=6.514, 5.678, 5.247, 9.472, P=0.037,0.042, 0.045, 0.013）; The incidence of adverse reactions in the experimental group was 5.33%, which was significantly lower than the incidence of adverse reactions in the control group 17.33%,（χ^2=6.584, P =0.036）, with statistical significance（P 0.05）. Conclusion Amoxicillin potassium clavulanate combined with azithromycin for the treatment of children with pneumonia is effective, safe and worthy of promotion.