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利格列汀对二甲双胍联合吡格列酮控制不佳的2型糖尿病治疗效果 被引量:3

Effect of Linagliptin on the Bad Controlled Patients with Type 2 Diabetes after Melbine and Pioglitazone
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摘要 目的研究利格列汀对二甲双胍联合吡格列酮控制不佳的2型糖尿病治疗的作用。方法选取2015年1月—2017年5月收治的56例经二甲双胍联合吡格列酮治疗效果不佳2型糖尿病患者,随机分为观察组、对照组,观察两组空腹血糖、餐后2 h血糖、HbA1c、HOMA-IR变化。结果治疗后观察组FBG、2 hPG、HbA1c均低于对照组,HOMAIR也低于对照组,不良反应发生率仅为3.57%,远较对照组的17.86%低,两组差异有统计学意义(P<0.05)。结论利格列汀对二甲双胍联合吡格列酮控制不佳的2型糖尿病治疗效果良好,能有效控制血糖水平。 Objective To research the effect of linagliptin on the bad controlled patients with type 2 diabetes after melbine and pioglitazone. Methods 56 cases of bad controlled patients with type 2 diabetes after melbine and pioglitazone admitted and treated in our hospital from January 2015 to May 2017 were randomly divided into two groups, and the changes of fasting blood glucose, postprandial 2 h blood glucose, HbA1c, HOMA-IR of the two groups were observed. Results After treatment, the FBG, 2 hPG, HbA1c in the observation group were lower than those in the control group, and the HOMA-IR was lower than that in the control group, and the incidence rate of adverse reactions was much lower than that in the control group(3.57% vs 17.86%), and the difference was statistically significant(P〈0.05). Conclusion The effect of linagliptin on the bad controlled patients with type 2 diabetes after melbine and pioglitazone is good, which can effectively control the blood glucose level.
作者 蔡文娟 CAI Wen-juan(Department of Endocrinology, Changchun People's Hospital, Changchun, Jilin Province, 130000 China)
出处 《糖尿病新世界》 2018年第8期84-85,共2页 Diabetes New World Magazine
关键词 利格列汀 二甲双胍 吡格列酮 控制不佳 2型糖尿病 Linagliptin Melbine Pioglitazone Bad controlled Type 2 diabetes
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  • 1熊旭明,陈晓辉,刘卫江,罗辉遇,谢长江,温德良.机械通气在严重乳酸性酸中毒抢救中的价值探讨[J].中国急救医学,2005,25(4):249-251. 被引量:18
  • 2Shaw JE, Sicree RA, Zimmet PZ.Global estimates of the prevalence of diabetes for 2010 and 2030[J].Diab Res Clin Pract,2010,87 ( 1 ): 4-14.
  • 3Yang W, Lu J, Weng J, et al.Prevalenee of diabetes among men and women in China[J].N Engl J Med,2010,362: 1090-1101. 2012.
  • 4ADA annual session concurrent meetings[J].J Am Dent Assoe,2012,143 ( 9 ) : 1031-1032.
  • 5Iannello S, Camuto M, Cavaleri A, et al.Effects of short- termmetformin treatment on insulin sensitivity of blood glucose and free fatty aeids[J].Diabetes Obes Metab, 2004 ( 1 ): 8-15.
  • 6Stang M, Wysowski DK, Butler-Jones D.Ineidenee of acidosis in metformin users[J].Diabetes Care, 1999,22:925-927.
  • 7Carlon R, Dal Cero P, Corbanese U, et al.Three cases of severe metformin-related lactic acidosis[J].European journal of anaesthesiology, 2010,27 ( 7 ) : 666-667.
  • 8Kramer W, Muller G, Girbig F, et al.Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor.II.Photoaffinity labeling of a 65 kDa protein by [3H]glimepiride[J].Biochim Biophys Acta, 1994, 1191 ( 2 ) : 278-290.
  • 9Muller G, Hartz D, Punter J, et al.Differential interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor.I.Binding characteristics[J].Biochim Biophys Acta, 1994, 1191 ( 2 ) : 267-277.
  • 10Peters N, Jay N, Cravoisy A, et al.Metformin-associated lactic acidosis in an intensive care unit[J].Crit Care, 2008,12: 149.

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