胰岛素联合西格列汀对比联合二甲双胍治疗老年2型糖尿病患者的效果观察

Observation on Effect of Insulin Combined with Sitagliptin and Insulin Combined with Melbine in Treatment of Senile Patients with Type 2 Diabetes

目的对比探究胰岛素联合西格列汀与联合二甲双胍治疗老年2型糖尿病患者的效果。方法以2017年1—12月为研究时间段,将该时间段在该院治疗的老年2型糖尿病患者患者80例作为研究对象,根据临床前瞻性研究原则,采用掷币随机法,将之分为两组,各40例,在应用胰岛素基础上,对照组联用二甲双胍,观察组联用西格列汀,对比两组治疗效果。结果治疗后,观察组在空腹血糖、餐后2 h血糖、血糖达标时间、Hb A1c等指标上,其数值均小于对照组,两组数据差异有统计学意义(P<0.05)。结论在胰岛素治疗老年2型糖尿病的基础上,联合西格列汀的临床疗效优于联用二甲双胍,值得采纳应用。

Objective To compare the effect of insulin combined with sitagliptin and insulin combined with melbine in treatment of senile patients with type 2 diabetes. Methods 80 cases of senile patients with type 2 diabetes treated in our hospital from January to December 2017 were selected and randomly divided into two groups with 40 cases in each, the observation group and the control group were respectively treated with insulin combined with sitagliptin and insulin combined with melbine, and the treatment effect was compared between the two groups. Results After treatment, the fasting blood glucose, postprandial 2 h blood glucose, blood glucose standards-reaching time and Hb A1 c in the observation group were lower than those in the control group, and the differences between groups were statistically significant（P〈0.05）. Conclusion The clinical curative effect of insulin combined with sitagliptin in treatment of senile patients with type 2 diabetes is better than that of insulin combined with melbine, which is worth recommendation and application.