精神分裂症伴代谢综合征认知功能研究

A study on cognitive function in schizophrenia with metabolic syndrome

目的探讨精神分裂症认知功能缺损的特征及影响因素。方法从住院超过两年的精神分裂症患者中选取代谢综合征患者(MS组)82例,不伴代谢综合征患者(非MS组)107例,对所有患者进行重复性成套神经心理状态测验(RBANS),并测量所有患者空腹血糖、高密度脂蛋白、甘油三酯、血压、腰围。结果 MS组腰围、血糖、甘油三酯、高血压比例均高于非MS组(P<0.05);MS组高密度脂蛋白低于非MS组(P<0.05)。MS组RBANS语言因子分高于非MS组(P<0.05)。所有入组患者和非MS组RBANS评分均与年龄呈负相关(P<0.05)。所有患者中男性RBANS评分高于女性(P<0.05),非MS组男性RBANS评分高于女性(P<0.05)。结论代谢综合征可能对精神分裂症患者言语功能存在一定影响,从而影响认知功能;性别和年龄可能是精神分裂症患者认知功能的影响因素。

Objective To explore the characteristics and influencing factors of cognitive impairment in schizophrenia.Methods A total of 189 schizophrenics being hospitalized more than 2 years were selected and divided into MS group（ schizophrenics with metabolic syndrome,82 cases） and non-MS group（ schizophrenics without metabolic syndrome,107 cases）. They were assessed with Repeatable Battery for the Assessment of Neuropsychological Status（ RBANS）,fasting bloodglucose,high-density lipoprotein,triglycerides,blood pressure and waistline. Results The proportion of hypertension and levels of waistline,fasting blood-glucose and triglycerides in MS group were all significantly higher than those in non-MS group（ P 〈0. 05）; and the level of high-density lipoprotein in MS group was significantly lower than that in non-MS group（ P 〈 0. 05）. The language factor score in RBANS in MS group was significantly higher than that in non-MS group（ P 〈 0. 05）. The total scores of RBANS in all selected inpatients and in non-MS group were negatively correlated with their ages（ P 〈 0. 05）. Among all the inpatients,the total score of RBANS in males was significantly higher than that in females（ P 〈 0. 05）. In non-MS group,the total score of RBANS in males was significantly higher than that in females（ P 〈 0. 05）. Conclusion Metabolic syndrome may impact the language function in schizophrenics,thus affecting their cognitive function,which may be influenced by gender and age.